Side Effects

Side Effects of Combogesic Tablets

If any of these serious side effects happen, stop taking Combogesic and tell your doctor immediately or go to the emergency room at your nearest hospital:
• vomiting blood or material that looks like coffee
grounds; • bleeding from the back passage, black sticky
bowel motions (stools) or bloody diarrhoea; • swelling of the face, lips or tongue which may cause difficulty in swallowing or breathing; • asthma, wheezing, shortness of breath; • very rare cases of serious skin reactions have
been reported including sudden or severe itching, skin rash, hives; • severe blisters and bleeding in the lips, eyes, mouth, nose and genitals (Stevens-Johnson
Syndrome) • a severe skin reaction known as DRESS
syndrome can occur. Symptoms of DRESS include: skin rash, fever, swelling of lymph nodes and an increase of eosinophils (a type of white blood cells). • fever, generally feeling unwell, nausea, stomachache, headache and stiff neck.
Other side effects:
Common (may affect up to 1 in 10 people): • fluid retention, swelling • ringing in the ears (tinnitus) • nausea or vomiting • loss of appetite • heartburn or pain in the upper part of your stomach • diarrhoea • skin rashes • headache • dizziness • change in liver or kidney function (established by blood tests)
Uncommon (may affect up to 1 in 100 people): • reduction in red blood cell numbers, bleeding episodes such as nosebleeds, abnormal or prolonged bleeding during menstrual periods, increased number of platelets • eye problems such as blurred or diminished vision, changes to the appearance of colours • wind and constipation. • increased sensitivity to allergic reactions,
angioaedema (symptoms may include itchy, sore red eyes) • breast enlargement (in males) • abnormally low blood sugar (hypoglycaemia) • change in mood, for example, depression, confusion, excessive emotional reactions • change in the desire to sleep (sleepiness or
sleeplessness) • difficulty urinating • thickening of respiratory secretions (mucous) have or have had other medical conditions including:
 heartburn, indigestion, stomach ulcer or any other stomach problems;
 vomiting blood or bleeding from back passage;
 severe skin reactions such as Stevens-Johnson syndrome;
 asthma;
 vision problems;
 tendency to bleed or other blood problems;
 bowel or intestinal problems such as ulcerative colitis or Crohn’s Disease
 swelling of ankles or feet;
 diarrhoea;
 inherited genetic or acquired disorder of certain enzymes that manifest with either neurological complications or skin problems or occasionally both i.e. porphyria;
 smallpox;
 autoimmune disease such as Lupus erythematosus