Lenzetto spray is a revolutionary Hormone Replacement Therapy that contains the female hormone oestrogens. It helps to relieve symptoms of menopause, such as hot flashes and night sweats, in postmenopausal women. With its easy-to-use spray applicator, Lenzetto provides fast relief from the discomforting symptoms of menopause.
Lenzetto spray is used in postmenopausal women with at least 6 months since their last natural period.
Lenzetto spray can also be used in women who have had surgery to remove their ovaries as this causes instant menopause.
Lenzetto is a spray solution that contains small amounts of medicine called estradiol. When sprayed onto the skin as directed, it passes through the skin into your bloodstream.
What is Lenzetto spray used for?
Relief of symptoms occurring after menopause
During the menopause, the amount of the oestrogen produced by a woman’s body drops. This can cause symptoms such as hot face, neck and chest (“hot flushes”). Lenzetto spray alleviates these symptoms after menopause. You will only be prescribed Lenzetto if your symptoms seriously hinder your daily life.
Lenzetto spray is indicated to treat oestrogen deficiency symptoms after menopause; when menstruation has
ceased following menopause. Symptoms of oestrogen deficiency include hot flushes (sudden waves of heat and sweating in the whole body), sleeping problems, irritability and dryness of the vagina.
The experience in treating women older than 65 years is limited.
Always use this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
Your doctor will aim to prescribe the lowest dose to treat your symptom for as short as necessary.
During the treatment, your doctor may adjust the dose according to your individual needs. Speak to your doctor if you think this dose is too strong or not strong enough.
If you have not had a hysterectomy (surgery to remove your womb), your doctor will give you tablets containing another hormone called progestogen to offset the effects of oestrogens on the lining of your womb. Your doctor will explain to you how to take these tablets. Withdrawal bleeding may occur at
the end of the progestogen treatment period. (See section “Unexpected bleeding”)
If you need to have surgery
If you are going to have surgery, tell the surgeon that you are using Lenzetto spray. You may need to stop using Lenzetto spray about 4 to 6 weeks before the operation to reduce the risk of a blood clot . Ask your doctor when you can start using Lenzetto again.
Where to apply Lenzetto spray
The spray should be applied to the dry and healthy skin of the inner forearm. If that is not possible, it should be applied on the inner thigh.
Do not apply Lenzetto to the breasts or any area near the breasts.
Do not allow other people or pets to touch the area of the skin where the spray was applied for
at least 60 minutes. If another person (especially a child) accidentally touches the area of your skin
where you sprayed Lenzetto, tell that person to wash the area of their skin with soap and water right
away. Therefore, the sprayed area should be covered with clothing 2 minutes after application of the
spray.
How much Lenzetto you should use
Your doctor will probably start you on the lowest dose (one spray per day) and you should talk with
your doctor about how well the medicine is working for you. If necessary, your doctor may increase
your dose to two sprays per day. The maximum daily dose is 3 sprays.
How often you will use Lenzetto
The total number of sprays (dose(s)) that your doctor has prescribed for you should be applied at the
same time each day.
The period of time you will continue to use Lenzetto
Talk to your doctor every 3-6 months about how long you should use Lenzetto for. You should only
use Lenzetto for as long as you need it to provide relief from hot flushes associated with menopause.
Other useful information
Sunscreens can alter the absorption of oestrogen from Lenzetto.
Avoid using sunscreen on the part of the skin where you intend to spray Lenzetto. However, if you
need to use sunscreen, it should be applied at least one hour prior to using Lenzetto.
Lenzetto should be used with caution under extreme temperature conditions, such as sauna or
sunbathing.
There is limited data suggesting that the rate and extent of absorption of Lenzetto may be reduced in
overweight and obese women. Please talk to your doctor. During the treatment your doctor may adjust
the dose according to your individual needs.
If you use more Lenzetto than you should
If you use more Lenzetto than you should, or if children have been using the medicine by accident,
contact your doctor or the hospital to get an opinion of the risk and advice on action to be taken.
If you use more Lenzetto than you should, you may feel sick, vomit and have withdrawal bleeding
(unusual vaginal bleeding).
If you forget to use Lenzetto
If you forget to use Lenzetto at your normal time, spray the medicine on as soon as you remember, and
then use it as you normally would the next day. If it is almost time for your next dose, just wait and
apply the next dose as you normally would. If you forget one or more doses one primer spraying with
the cover on is needed. Do not use a double dose to make up for a forgotten dose. Forgetting a dose
may increase the likelihood of breakthrough bleeding and spotting.
If you have any further questions about how to use this product, ask your doctor or pharmacist.
If you stop using Lenzetto
Your doctor will also explain how to stop using this medicine when your treatment is finished.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Side Effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
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The following diseases are reported more often in women using HRT compared to women not using
HRT:
– breast cancer;
– abnormal growth or cancer of the lining of the womb (endometrial hyperplasia or cancer);
– ovarian cancer;
– blood clots in the veins of the legs or lungs (venous thromboembolism);
– heart disease;
– stroke;
– gall bladder disease;
– high blood pressure;
– liver problems;
– high blood sugar;
– probable memory loss if HRT is started over the age of 65.
For more information about these side effects, see Section 2.
Some side effects can be serious.
The following symptoms need immediate medical attention:
– sudden chest pain;
– pain in your chest that spreads to your arm or neck;
– breathing difficulties;
– painful swelling and redness in the legs;
– yellowing of the eyes and face (jaundice);
– unexpected vaginal bleeding (breakthrough bleeding) or spotting after using Lenzetto for some
time or after you stop treatment;
– breast changes including dimpling of the breast skin, changes in the nipple, lumps that you can
see or feel;
– painful menstrual periods;
– dizziness and faintness;
– changes in speech;
– changes in vision;
– unexplained migraine-like headaches.
If any of the side effects get serious, or if you notice any side effects not listed in this leaflet, please
tell your doctor or pharmacist.
The following side effects below have been reported with Lenzetto:
Common side effects (may affect up to 1 in 10 people)
Headache, abdominal pain, nausea, rash, pruritis (itching), irregular uterine bleeding or vaginal
bleeding including spotting, breast tenderness, breast pain, weight increase or weight decrease.
Uncommon side effects (may affect up to 1 in 100 people)
Hypersensitivity reactions, depressed mood, insomnia (difficulty sleeping), dizziness, vertigo (a
feeling of dizziness or “spinning”), visual disturbances, palpitations (feeling your heartbeat),
diarrhoea, dyspepsia (indigestion), increased blood pressure, erythema nodosum (characterized by
painful reddish skin nodules), hives (general or localised rash or lumps), skin irritation, swelling due
to fluid retention (oedema), muscle pain, breast discolouration, breast discharge, polyps (small
growths) in the uterine or cervix, endometrial hyperplasia, ovary cyst, inflammation of genitals
(vaginitis), increased liver enzymes and blood cholesterol, underarm pain.
Rare side effects (may affect up to 1 in 1000 people)
Anxiety, decrease or increase in sexual drive, migraine, intolerance to contact lenses, bloating,
vomiting, increased body hair, acne, muscle cramps, painful menstruation, premenstrual like
syndrome, breast enlargement, fatigue.
Warnings
What you need to know before you use Lenzetto
Medical history and regular check-ups
The use of HRT carries risks which need to be considered when deciding whether to start using it, or
whether to carry on using it.
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The experience in treating women with a premature menopause (due to ovarian failure or surgery) is
limited. If you have a premature menopause the risks of using HRT may be different. Please talk to
your doctor.
Before you start (or restart) HRT, your doctor will ask about your own and your family’s medical
history. Your doctor may decide to perform a physical examination. This may include an examination
of your breasts and/or an internal examination, if necessary.
Once you have started on Lenzetto you should see your doctor for regular check-ups (at least once a
year). At these check-ups, discuss with your doctor the benefits and risks of continuing with Lenzetto.
Go for regular breast screening, as recommended by your doctor.
Do not use Lenzetto
if any of the following applies to you. If you are not sure about any of the points below, talk to your
doctor before using Lenzetto.
Do not use Lenzetto – if you have or have ever had breast cancer, or if you are suspected of having it; – if you have cancer which is sensitive to oestrogens, such as cancer of the womb lining
(endometrium), or if you are suspected of having it; – if you have any unexplained vaginal bleeding; – if you have excessive thickening of the womb lining (endometrial hyperplasia) that is not being
treated; – if you have or have ever had a blood clot in a vein (thrombosis), such as in the legs (deep venous
thrombosis) or the lungs (pulmonary embolism); – if you have a blood clotting disorder (such as protein C, protein S or antithrombin
deficiency); – if you have, or recently have had a disease caused by blood clots in the arteries, such as heart
attack, stroke or angina; – if you have, or have ever had, a liver disease and your liver function tests have not returned to
normal; – if you have a rare blood problem called “porphyria” which is passed down in families (is
inherited); – if you are allergic to estradiol or any of the other ingredients of this medicine (listed in section 6).
If any of the above conditions appear for the first time while using Lenzetto, stop using it at once and
consult your doctor immediately.
Warnings and precautions
Talk to your doctor or pharmacist before using Lenzetto.
Tell your doctor if you have ever had any of the following problems, before you start the treatment, as
these may return or become worse during treatment with Lenzetto. If so, you should see your doctor
more often for check-ups: – fibroids inside your womb; – growth of womb lining outside your womb (endometriosis) or a history of excessive growth of
the womb lining (endometrial hyperplasia); – increased risk of developing blood clots (see “Blood clots in a vein (thrombosis)”); – increased risk of getting an oestrogen-sensitive cancer (such as having a mother, sister or
grandmother who has had breast cancer); – high blood pressure; – a liver disorder such as a benign liver tumour; – diabetes; – gallstones; – migraine or severe headaches;
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– a disease of the immune system that affects many organs of the body (systemic lupus
erythematosus, SLE); – epilepsy; – asthma; – a disease affecting the eardrum and hearing (otosclerosis); – a very high level of fat in your blood (triglycerides); – fluid retention due to cardiac or kidney problems.
Stop using Lenzetto and see a doctor immediately
If you notice any of the following when using HRT: – any of the conditions mentioned in the “DO NOT use Lenzetto” section; – yellowing of your skin or the whites of your eyes (jaundice). These may be signs of a liver
disease; – a large rise in your blood pressure (symptoms may be headache, tiredness, dizziness); – migraine-like headaches which happen for the first time; – if you become pregnant; – if you notice signs of a blood clot, such as: – painful swelling and redness of the legs; – sudden chest pain; – difficulty in breathing.
For more information, see ‘Blood clots in a vein (thrombosis)’.
Waited a week for delivery after prescription had been received even though I paid for next day delivery. Tried contacting the company to ask why and no one answered my call
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Helen W. (verified owner) –
Helen Walker
Sarah Abdy (verified owner) –
Julie Cutbush –
Hello Customer. Thanks so much for your 5-star review! We’re glad to hear about positive experience using LENZETTO. we hope to see you again soon.
Julie Cutbush –
Hello Customer. Thanks so much for your 4-star review! We’re glad to hear about positive experience using LENZETTO. we hope to see you again soon.
Alison (verified owner) –
Julie Cutbush –
Hello Customer. Thanks so much for your 5-star review! We’re glad to hear about positive experience using Lenzetto. we hope to see you again soon.
Kind Regards Dock Pharmacy
Anonymous (verified owner) –
Product matched expectations
Rachel Galea-Baker (verified owner) –
Anonymous (verified owner) –
As expected
Tracy S. (verified owner) –
I have not received my order yet.
Julie Cutbush –
DearTracy
unfortunately we can not supply Lenzetto without a prescription – we are still waitingforyourself to provide one.
kind regards
Isobel Pike (verified owner) –
Waited a week for delivery after prescription had been received even though I paid for next day delivery. Tried contacting the company to ask why and no one answered my call