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- Description
- Additional Information
- Brand
- How To Use
- Product Details
- Side Effects
- Ingredients
- How to Store
- Patient Information leaflet
- Reviews (2)
- Questions & Answers (1)
Actikerall Solution – Fluorouracil and Salicylic acid Solution, 25ml
Actikerall solution contains two active substances, fluorouracil and salicylic acid. It is indicated for the treatment of actinic keratosis (grade I/II) in adult patients with a healthy immune system.
Actikerall works by causing the death of abnormal cells that are present in actinic keratosis lesions. This leads to the shedding of the lesion and the formation of new, healthy skin cells.
Actikerall is easy to use and is applied topically to the affected area(s) once daily for 3-4 weeks. Treatment with Actikerall may cause some skin irritation, redness, and peeling. These side effects are usually mild and temporary.
How does Actikerall Solution work?
Fluorouracil belongs to a group of medicines known as antimetabolites, which inhibit the growth of cells (cytostatic agent). Salicylic acid is a substance to soften hard skin.
Actikerall Solution Reviews
After using Actikerall Solution, it’s helpful to let others know about your experience. Reviews of an item help other users know that medicines received have helped the condition it is claimed for, how well the treatment worked or any issues to be aware of. We invite our users to leave a review of both their treatment and of the service provided. Click on the reviews tab to see if there has been feedback on this item.
What is the price of Actikerall Solution?
The price of Actikerall Solution is £57.45
Where can you buy Actikerall Solution?
You can buy Actikerall Solution at Dock Pharmacy Essex UK, UK Online Pharmacy.
Can you buy Actikerall Solution Over the counter?
Actikerall Solution is not available to buy over the counter. You need a prescription to buy Actikerall Solution
| Brand | |
|---|---|
Brand
ACTIKERALL
How To Use
How To Use Actikerall Solution
Always use this medicine exactly as your doctor has told you. Check with your doctor or pharmacist, if you are not sure.
Dosage
Actikerall should be applied once daily unless your doctor has told you otherwise.
If you have an actinic keratosis in an area of thin skin e.g. around the eyes and temple, your doctor may tell you to apply Actikerall less frequently. If severe side effects occur, reduce the frequency of drug application to three times per week until the side effects improve. It may also be necessary for your doctor to monitor your treatment more often.
Method of administration
For application to the skin (cutaneous use).
- Remove the white film on your skin from the previous day’s application by gently peeling it off (unless this is the first time you have used this medicine). Warm water may help to remove the film.
- To open the bottle, press the lid down and turn.
- Remove excess solution from the brush by wiping it in the neck of the bottle. Although allowing enough product for film formation upon drying.
- Dab the solution on the actinic keratosis once daily.
- Multiple actinic keratoses (up to 10 lesions) can be treated simultaneously, but do not use on large areas of skin.
- The total area of skin being treated with Actikerall at any one time should not exceed 25 cm2 (5 cm x 5 cm).
- Let the solution dry and form a film.
- Do not cover with a dressing.
- Close the bottle tightly to prevent it drying out. If Actikerall dries out, it must not be used any longer. Do not use Actikerall if you notice any crystals.
- Do not apply to hairy skin due to sticking together of the hair in the skin area where Actikerall is applied, making it difficult to remove the film. When applied to hairy skin, a shave or other suitable methods of hair removal should be considered prior to any application.
Further instructions
Actikerall must not be allowed to come into contact with the eyes, the inside of the mouth or nose or the genitals (mucous membranes).
Actikerall solution may permanently stain clothing, fabric or acrylics (such as acrylic bathtubs), so avoid contact with them.
Caution flammable: keep away from fire and do not use near an open flame, lit cigarette or some devices (e.g. hairdryers).
Consult your doctor regularly during treatment.
Duration of treatment
Actikerall is applied to actinic keratoses once daily until the lesions have completely cleared or for up to a maximum of 12 weeks. Improvement of actinic keratoses can be seen as early as 4 weeks after starting treatment and the improvement increases over time up to 12 weeks. The clearance of actinic keratoses may continue for up to 8 weeks after stopping treatment. Treatment should be continued even in the absence of any effect after the first 4 weeks.
If you have the impression that the effect of Actikerall is too strong or too weak, talk to your doctor or pharmacist.
If you use more Actikerall than you should
If you apply Actikerall more often than once daily, you will be more likely to experience skin reactions and they may be more severe. In this case, please contact your doctor.
If you forget to use Actikerall
Do not use a double dose to make up for a forgotten dose. Continue your treatment as the doctor has told you or as described in this leaflet.
If you stop using Actikerall
Please contact your doctor, if you want to stop treatment.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Product Details
Actikerall Solution Product Information
What you need to know before you use Actikerall
Do not use Actikerall
- if you are allergic to fluorouracil, salicylic acid or any of the other ingredients of this medicine (listed in section 6).
- while breast-feeding.
- during pregnancy, and if there is a possibility that you might be pregnant.
- if you have kidney problems.
- if it could come into contact with the eyes, the inside of the mouth or nose or the genitals (mucous membranes).
Certain other medicines can intensify the side effects of Actikerall or lead to other side effects. See ‘Other medicines and Actikerall’ below.
Warnings and precautions
Talk to your doctor or pharmacist before using Actikerall
- if you kow that you do not have any activity of the enzyme dihydropryrimidine dehydrogenase (DPD) (complete DPD deficiency). It is important that you do not apply more Actikerall than indicated in section 3 of this package leaflet.
- if you suffer from a reduced ability to sense touch, pain and temperature (if you have diabetes, for example). In this case, your treatment areas must be closely monitored by your doctor.
- Actikerall should not be used on bleeding lesions.
- The area treated should be protected against direct sunlight as much as possible while using Actikerall and the patient must not use a sunlamp or sun bed.
- There is no experience with Actikerall for the treatment of skin cancers such as rodent ulcer (BCC) and Bowen’s disease, which should therefore not be treated with the product.
- In treating an area with actinic keratosis that is also affected by another skin disease it should be taken into account that the outcome of treatment may differ.
- There is no experience with Actikerall for repeated treatment cycles in patients with actinic keratosis or for retreatment, if a lesion comes back.
Children and adolescents
Actikerall should not be used in children or adolescents under 18 years of age. Children usually do not get actinic keratosis.
Other medicines and Actikerall
Tell your doctor or pharmacist, if you are using, have recently taken or might take any other medicines. If several medicines are taken at the same time, the effect of individual medicines can be intensified or weakened.
In particular tell your doctor, if you take any of the following:
- medicines used to treat viruses such as chicken pox or shingles (brivudine, sorivudine or similar medicines). You must not use Actikerall, if you are using or have used any of these medicines in the past 4 weeks as it may result in increased side effects.
- epilepsy medicine (phenytoin). Using Actikerall may lead to elevated blood levels of phenytoin.
- medicine used to treat cancer and auto-immune diseases (methotrexate). This medicine may interact with Actikerall causing undesirable effects.
- medicine used to treat diabetes (sulfonylureas). This medicine may interact with Actikerall causing undesirable effects.
Pregnancy, breast-feeding and fertility
You must not use Actikerall while breast-feeding, during pregnancy and if there is a possibility that you might be pregnant.
Driving and using machines
No special precautions are required.
Actikerall contains dimethyl sulfoxide and ethanol. Dimethyl sulfoxide may be irritant to the skin. This medicine contains 160 mg alcohol (ethanol) in each gram. It may cause burning sensation on damaged skin.
Side Effects
Actikerall Solution Side Effects
Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Mild to moderate irritation and inflammation at the site of application occur in the majority of patients treated with Actikerall. If these reactions get severe, please contact your treating doctor.
As this medicine has a very strong softening effect on the skin, whitish discolorations and scaling of the skin may occur.
The salicylic acid in Actikerall may cause slight irritation, such as skin inflammation (dermatitis) and contact allergic reactions, in patients with sensitive skin or allergy to salicylic acid. Symptoms of contact allergic reactions may include itching, reddening and small blisters even outside the area of application.
Side effects can occur with the following frequencies:
Very common, may affect more than 1 in 10 people
- reactions at the application site
- skin redness (erythema), inflammation, irritation (including burning), pain, itch
Common, may affect up to 1 in 10 people
- headache
- skin scaling (exfoliation)
- reactions at the application site
- mild bleeding, loss of the top layer of skin (erosion), scab
Uncommon, may affect up to 1 in 100 people
- dry eye, itching eye, increased watery eyes (lacrimation)
- reactions at the application site
- skin inflammation (dermatitis), swelling (oedema), ulcer
Mild bleeding, loss of the top layer of skin (erosion), scab, swelling (oedema), ulcer and skin inflammation (dermatitis) frequencies were one category higher in one study when applying Actikerall on an affected area of 25 cm2
Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme, Website: www.mhra.gov.uk/yellowcard.
By reporting side effects you can help provide more information on the safety of this medicine.
Ingredients
Ingredients of Actikerall Solution
What Actikerall contains
The active substances are fluorouracil and salicylic acid.
1 g (= 1.05 ml) of cutaneous solution contains 5 mg of fluorouracil and 100 mg of salicylic acid.
The other ingredients are: dimethyl sulfoxide; ethanol, anhydrous; ethyl acetate; pyroxyline; poly(butyl methacrylate, methyl methacrylate).
How to Store
How to Store Actikerall Solution
Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the label and on the carton after EXP. The expiry date refers to the last day of that month.
Do not store above 25 °C. Do not refrigerate or freeze. Keep the bottle tightly closed to prevent drying up.
Caution flammable: keep away from fire and do not use near an open flame, lit cigarette or some devices (e.g. hairdryers).
Do not use Actikerall 3 months after first opening of the bottle.
Do not use Actikerall if you notice crystals.
Do not throw away any medicines via wastewater <or household waste>. Ask your pharmacist how to throw away medicines you no longer use. These measures will help to protect the environment.
Patient Information leaflet
Click here for the Patient Information leaflet of Actikerall Solution
Please read before using the product
2 reviews for Actikerall Solution – Fluorouracil and Salicylic acid Solution, 25ml
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