Atovaquone/Proguanil Hydrochloride tablets are a prescription medication used to prevent and treat malaria. The two active ingredients, atovaquone and proguanil hydrochloride, work together to kill the malaria parasite inside red blood cells.
Atovaquone / Proguanil Hydrochloride Tablets is the generic for Malarone tablets
What is Atovaquone / Proguanil Hydrochloride Tablets used for?
Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets have two uses:
to prevent malaria in adults and children who weigh more than 40 kg
to treat malaria in adults and children who weigh more than 11 kg
What is Malaria?
Malaria is a serious tropical disease that can be fatal if not treated promptly. A single mosquito bite leads to infection.
It’s important to be aware of the symptoms of malaria if you’re travelling to areas where there’s a high risk of the disease.
Symptoms of malaria can develop as quickly as 7 days after you’re bitten by an infected mosquito.
Typically, the time between being infected and when symptoms start (incubation period) is 7 to 18 days, depending on the specific parasite you’re infected with. However, in some cases it can take up to a year for symptoms to develop.
The initial symptoms of malaria are flu-like and include:
These symptoms are often mild and can sometimes be difficult to identify as malaria.
How to protect yourself from malaria?
People of any age can get malaria. It is a serious disease, but it is preventable. As well as taking Maloff Protect, it is very important that you also take steps to avoid being bitten by mosquitoes. The bite avoidance measures listed below should be used in combination for maximum effectiveness.
Use insect repellent on exposed areas of the skin.
Wear clothing that covers most of the body, especially after sunset as this is the time when mosquitoes are most active.
Sleep in a room with screened windows and doors or under a mosquito net (it is preferable to sleep under a mosquito net treated with insecticide if possible).
Close windows and doors at sunset, if they are not screened.
Sleep in a room with air-conditioning or a fan, as mosquitoes are less active in cooler temperatures.
Consider using an insecticide (mats, spray, plug-ins) to clear a room of insects or to stop mosquitoes from entering the room.
How To take Atovaquone / Proguanil Hydrochloride Tablets
Always take Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
Take Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets with food or a milky drink, where possible.
It is best to take Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets at the same time each day.
For preventing malaria
The usual dose for adults and adolescents weighing more than 40 kg is 1 tablet once a day, taken as below.
For children, talk to your doctor.
Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets is not recommended for preventing malaria in children, or in adults or adolescents who weigh less than 40 kg.
There may be a different type of Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets available for children in your country.
To prevent malaria in adults:
start taking Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets 1 to 2 days before travelling to an area which has malaria
continue taking it every day during your stay and then continue taking it for another 7 days after your return to a malaria-free area. Take the full course of Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets for maximum protection. Stopping early puts you at risk of getting malaria, as it takes 7 days to ensure that any parasites that may be in your blood following a bite from an infected mosquito are killed.
For treating malaria:
The usual dose for adults is 4 tablets once a day for 3 days.
For children weighing 11 kg or more:
≥11 to <20 kg – 1 tablet once a day for 3 days
≥ 21 to <30 kg – 2 tablets once a day for 3 days
≥ 31 to <40 kg – 3 tablets once a day for 3 days
Over 40 kg – dose as for adults.
Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets is not recommended for treating malaria in children who weigh less than 11 kg.
For children who weigh less than 11 kg talk to your doctor. There may be a different type of Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablet available in your country
If you take more Atovaquone/Proguanil Hydrochloride than you should
Contact a doctor or pharmacist for advice. If possible show them the Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets pack.
If you forget to take Atovaquone/Proguanil Hydrochloride
It is very important that you take the full course of Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets. If you forget to take a dose, don’t worry. Just take your next dose as soon as you remember. Then continue your treatment as before. Don’t take a double dose to make up for a missed dose.
Don’t stop taking Atovaquone/Proguanil Hydrochloride without advice
Keep taking Atovaquone/Proguanil Hydrochloride for 7 days after you return to a malaria-free area. Take the full course of Atovaquone/Proguanil Hydrochloride for maximum protection. Stopping early puts you at risk of getting malaria, as it takes 7 days to ensure that any parasites that may be in your blood following a bite from an infected mosquito are killed.
Please talk to your doctor or pharmacist if you need any advice.
If you have any further questions on the use of this product, ask your doctor or pharmacist.
Delivery Options
Delivery options
All deliveries are subject to the availability of the product and product sale conditions been met.
Order & Collect
Free next-day collection from In-Store
UK Delivery
Standard Delivery within the UK £3.50 Delivery time 3-4 days First Class Delivery within the UK £5.90 Delivery time 1-2 days Priority Delivery within the UK £7.10. Next day delivery by 1pm. Order must be placed by 1pm. Priority delivery is only available Monday to Thursday.
Europe Delivery
Standard Delivery within EEC from £12.50 Delivery time up to 5 days depending on the local delivery service within your country. Expedited Delivery within EEC £39.50 Delivery time 2 days. Delivery by DHL, UPS or TNT.
Rest of the World
Standard Delivery Rest of the World from £16.10 Delivery Time 10 – 15 Days Expedited Delivery Rest of the World £55.09 Delivery 5 days. Delivery service by DHL, TNT or UPS
Atovaquone / Proguanil Hydrochloride Tablets Product Information
Do not take Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets:
if you are allergic to Atovaquone and/or proguanil hydrochloride or any of the ingredients of this medicine (listed in section 6).
for preventing malaria, if you have severe kidney disease.
Warnings and precautions
When preventing malaria:
if you are sick (vomit) within 1 hour of taking your Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablet, take another dose straight away
it is important to take the full course of Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets. If you have to take extra tablets due to sickness, you may need another prescription.
if you have been vomiting, it is especially important to use extra protection, such as repellents and bednets. Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets may not be as effective, as the amount absorbed will be reduced.
When treating malaria:
if you have vomiting and diarrhoea tell your doctor, you will need regular blood tests. Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets will not be as effective, as the amount absorbed will be reduced. The tests will check whether the malaria parasite is being cleared from your blood.
if you have severe kidney disease, your doctor may want to prescribe a different medicine
if you get a certain type of infection whilst being treated with Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets, your doctor may prescribe another type of medicine instead of Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets
if the malaria is treated but then comes back repeatedly or if the malaria is caused by a certain type of parasite, your doctor may prescribe another medicine to be taken as well as Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets
Other medicines and Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
Some medicines can affect the way Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets works, or Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets themselves can strengthen or weaken the effectiveness of other medicines taken at the same time. These include:
metoclopramide, used to treat nausea and vomiting
the antibiotics tetracycline, rifampicin and rifabutin
efavirenz or certain highly active protease-inhibitors used to treat HIV
indinavir, used to treat HIV
warfarin and other medicines that stop blood clotting
etoposide used to treat cancer.
Tell your doctor if you are taking any of these. Your doctor may decide that Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets aren’t suitable for you, or that you need extra check ups while you’re taking it.
REMEMBER to tell your doctor if you start taking any other medicines while you’re taking Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets.
Atovaquone/Proguanil Hydrochloride with food and drink
Take Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets with food or a milky drink, where possible. This will increase the amount of Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets your body can absorb, and make your treatment more effective.
The tablets should preferably not be crushed.
Pregnancy and breast-feeding
If you are pregnant or if you have the intention to get pregnant, do not take Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets unless your doctor recommends it.
Ask your doctor or pharmacist for advice before taking Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets.
Do not breast feed while taking Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets, as the ingredients of Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets may pass into breast milk and may harm your baby.
Driving and using machines
If you feel dizzy, do not drive. Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets make some people feel dizzy. If this happens to you, do not drive, use machines or take part in activities where you may put yourself or others at risk.
Side Effects
Atovaquone / Proguanil Hydrochloride Tablets Side Effects
POSSIBLE SIDE EFFECTS
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Look out for the following severe reactions. They have occurred in a small number of people, but their exact frequency is unknown.
Severe allergic reactions – signs include:
rash and itching
sudden wheezing, tightness of the chest or throat, or difficulty breathing
swollen eyelids, face, lips, tongue or other part of the body.
Contact a doctor immediately if you get any of these symptoms. Stop taking Atovaquone/Proguanil Hydrochloride 250 mg/100 mg Film-coated tablets.
Severe skin reactions:
skin rash, which may blister and looks like small targets (central dark spots, surrounded by paler area with a dark ring around the edge) (erythema multiforme)
severe widespread rash with blisters and peeling skin, particularly occurring around the mouth, nose, eyes and genitals (Stevens-Johnson syndrome). If you notice any of these symptoms contact a doctor urgently.
Most of the other side effects reported have been mild and have not lasted very long.
Very common: affects more than 1 user in 10
headache
feeling sick and being sick (nausea and vomiting)
stomach pain
diarrhoea
Common: affects 1 to 10 users in 100
dizziness
sleeping problems (insomnia)
strange dreams
depression
loss of appetite
fever
rash
cough
allergic reactions
itching (pruritus)
Common side effects, which may show up in your blood tests are:
reduced numbers of red blood cells (anaemia) which can cause tiredness, headaches and shortness of breath
reduced numbers of white blood cells (neutropenia) which may make you more likely to catch infections
low levels of sodium in the blood (hyponatraemia)
an increase in liver enzymes.
Uncommon: affects 1 to 10 users in 1,000
These may affect up to 1 in 100 people:
anxiety
an unusual awareness of abnormal beating of the heart (palpitations) swelling and redness of the mouth
red swollen patches on the skin (hives)
hair loss.
Uncommon side effects that may show up in your blood tests:
an increase in amylase (an enzyme produced in the pancreas).
Rare: affects 1 to 10 users in 10,000
seeing or hearing things that are not there (hallucinations)
Other side effects: Other side effects have occurred in a small number of people but their exact frequency is unknown.
Inflammation of the liver (hepatitis)
blockage of the bile ducts (cholestatis)
increase in heart rate (tachycardia)
inflammation of the blood vessels (vasculitis) which may be visible as red or purple raised spots on the skin but can affect other parts of the body
fits (seizure)
panic attacks, crying
nightmares
severe mental health problem in which the person loses contact with reality and is unable to think and judge clearly
mouth ulcers
blisters
peeling skin
increased sensitivity of the skin to sunlight
effects on your stomach (gastric intolerance).
Other side effects that may show up in your blood tests:
Adecrease in all types of blood cells (pancytopenia).
Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via Yellow Card Scheme at: www.mhra.gov.uk/yellowcard. By reporting side effects you can help provide more information on the safety of this medicine.
The active substances are atovaquone and proguanil hydrochloride.
Each tablet contains 250 mg atovaquone and 100 mg proguanil hydrochloride.
The other ingredients are:
Core
Poloxamer 188 , Microcrystalline Cellulose, Low-substituted Hydroxypropyl Cellulose, Povidone K30, Sodium Starch Glycolate Type A, Silica Colloidal anhydrous, Magnesium Stearate
Coating
Hypromellose, Titanium Dioxide (E171), Iron Oxide Red (E172), Macrogol 400, Macrogol 8000
How to Store
How to Store Atovaquone / Proguanil Hydrochloride Tablets
Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the carton and the blister after EXP. The expiry date refers to the last day of that month.
This medicinal product does not require any special storage conditions.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
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