Looking to conceive through assisted reproductive techniques? Cetrotide Injection may help you achieve your goal by delaying the release of eggs until they can be collected. With this medication, you’ll have a better chance of success with ART procedures. Talk to your doctor to see if Cetrotide is right for you.
Cetrotide 0.25mg Injection contains a medicine called ‘cetrorelix’. This medicine stops your body from releasing an egg from your ovary (ovulation) during your menstrual cycle.
Cetrotide belongs to a group of medicines called ‘anti-gonadotropin-releasing hormones’.
How does Cetrotide Injection work?
Cetrotide blocks a natural hormone in your body called LHRH (‘luteinising hormone releasing hormone’).
• LHRH controls another hormone, called LH (‘luteinising hormone’).
• LH stimulates ovulation during your menstrual cycle. This means that Cetrotide stops the chain of events that leads to an egg being released from your ovary. When your eggs are ready to be collected, another medicine will be given to you that will release them (ovulation induction)
What is Infertility
Infertility is when a couple cannot get pregnant (conceive) despite having regular unprotected sex.
Around 1 in 7 couples may have difficulty conceiving.
About 84% of couples will conceive naturally within a year if they have regular unprotected sex (every 2 or 3 days).
For couples who have been trying to conceive for more than 3 years without success, the likelihood of getting pregnant naturally within the next year is 1 in 4, or less.
Some people get pregnant quickly, but for others it can take longer. It’s a good idea to see a GP if you have not conceived after a year of trying.
Women aged 36 and over, and anyone who’s already aware they may have fertility problems, should see their GP sooner.
surgical procedures such as treatment for endometriosis, repair of the fallopian tubes, or removal of scarring (adhesions) within the womb or abdominal cavity
Some treatments for infertility, such as IVF, can cause complications.
For example:
multiple pregnancy – if more than 1 embryo is placed in the womb as part of IVF treatment there’s an increased chance of having twins; this may not seem like a bad thing, but it significantly increases the risk of complications for you and your babies
ectopic pregnancy – the risk of having an ectopic pregnancy is slightly increased if you have IVF
There are many possible causes of infertility, and fertility problems can affect either partner. But in a quarter of cases it is not possible to identify the cause.
Common causes of infertility include:
lack of regular ovulation (the monthly release of an egg)
poor quality semen
blocked or damaged fallopian tubes
endometriosis – where tissue that behaves like the lining of the womb (the endometrium) is found outside the womb
RISK FACTORS
There are also several factors that can affect fertility.
These include:
age – fertility declines with age
weight – being overweight or obese (having a BMI of 30 or over) reduces fertility; in women, being overweight or severely underweight can affect ovulation
sexually transmitted infections (STIs) – several STIs, including chlamydia, can affect fertility
smoking – can affect fertility: smoking (including passive smoking) affects your chance of conceiving and can reduce semen quality; read more about quitting smoking
alcohol – the safest approach is not to drink alcohol at all to keep risks to your baby to a minimum. Drinking too much alcohol can also affect the quality of sperm (the chief medical officers for the UK recommend adults should drink no more than 14 units of alcohol a week, which should be spread evenly over 3 days or more)
environmental factors – exposure to certain pesticides, solvents and metals has been shown to affect fertility, particularly in men
stress – can affect your relationship with your partner and cause a loss of sex drive; in severe cases, stress may also affect ovulation and sperm production
There’s no evidence to suggest caffeinated drinks, such as tea, coffee and colas, are associated with fertility problems.
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Always use this medicine exactly as your doctor has told
you. Check with your doctor if you are not sure
Using this medicine
This medicine is only for injection just under the skin of your belly (subcutaneous). To reduce skin irritation, select a different part of your belly each day.
• Your doctor must supervise your first injection.
Your doctor or nurse will show you how to prepare and inject the medicine.
• You can carry out the following injections yourself as long as your doctor has made you aware of the symptoms that may indicate allergy and of the possibly serious or life-threatening consequences that would need immediate treatment (See Section 4 ‘Possible side effects’).
• Please carefully read and follow the instructions at the end of this leaflet called ‘How to mix and inject Cetrotide’.
• You start by using another medicine on day 1 of your treatment cycle. You then start using Cetrotide a few days later. (See next section ‘How much to use’).
How much to use
Inject the contents of one vial (0.25 mg Cetrotide) once each day. It is best to use the medicine at the same time each day, leaving 24 hours between each dose.
You can choose to inject every morning or every evening.
• If you are injecting every morning: Start your injections on day 5 or 6 of the treatment cycle. Based on your ovarian response, your doctor may decide to start on another day. Your doctor will tell you the exact date and time. You will keep using this medicine up until
and including the morning that your eggs are collected (ovulation induction).
OR
• If you are injecting every evening: Start your injections on day 5 of the treatment cycle. Based on your ovarian response, your doctor may decide to start on another day. Your doctor will tell you the exact date and time.
You will keep using this medicine up until and including the evening before your eggs are collected (ovulation induction).
If you use more Cetrotide than you should
Bad effects are not expected if you accidentally inject more of this medicine than you should. The effect of the medicine will last for longer. No specific measures are usually required.
If you forget to use Cetrotide
• If you forget a dose, inject it as soon as you remember and talk to your doctor.
• Do not inject a double dose to make up for a forgotten dose.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Delivery Options
Delivery options
All deliveries are subject to the availability of the product and product sale conditions been met.
Order & Collect
Free next-day collection from In-Store
UK Delivery
Standard Delivery within the UK £3.50 Delivery time 3-4 days First Class Delivery within the UK £5.90 Delivery time 1-2 days Priority Delivery within the UK £7.10. Next day delivery by 1pm. Order must be placed by 1pm. Priority delivery is only available Monday to Thursday.
Europe Delivery
Standard Delivery within EEC from £12.50 Delivery time up to 5 days depending on the local delivery service within your country. Expedited Delivery within EEC £39.50 Delivery time 2 days. Delivery by DHL, UPS or TNT.
Rest of the World
Standard Delivery Rest of the World from £16.10 Delivery Time 10 – 15 Days Expedited Delivery Rest of the World £55.09 Delivery 5 days. Delivery service by DHL, TNT or UPS
What you need to know before you use Cetrotide
Do not use Cetrotide
• if you are allergic to cetrorelix or any of the other ingredients of this medicine (listed in section 6) if you are allergic to medicines similar to Cetrotide (any other peptide hormones)
• if you are pregnant or breast-feeding
• if you have severe kidney disease.
Do not use Cetrotide if any of the above applies to you.
If you are not sure, talk to your doctor before using this medicine.
Warnings and precautions
Allergies
Tell your doctor before using Cetrotide if you have an active allergy or have had allergies in the past.
Ovarian Hyper-stimulation Syndrome (OHSS)
Cetrotide is used together with other medicines that stimulate your ovaries to develop more eggs ready to be released.
During or after you receive these medicines, you may develop OHSS. This is when your follicles develop too much and become large cysts. For possible signs to look out for and what to do if this happens see section 4 ‘Possible side effects’.
Using Cetrotide during more than one cycle
Experience of using Cetrotide during more than one cycle is small. Your doctor will carefully look at the benefits and risks for you, if you need to have Cetrotide during more than one cycle.
Liver disease
Tell your doctor before using Cetrotide if you have a liver disease. Cetrotide has not been investigated in patients with hepatic disease.
Kidney disease
Tell your doctor before using Cetrotide if you have a kidney disease. Cetrotide has not been investigated in patients with kidney disease.
Children and adolescents
Cetrotide is not indicated for the use in children and adolescents.
Other medicines and Cetrotide
Tell your doctor if you are using, have recently used or might use any other medicines.
Pregnancy and breast-feeding
Do not use Cetrotide if you are pregnant, think you may be pregnant, or if you are breast-feeding.
Driving and using machines
Cetrotide is not expected to affect your ability to drive and use machines.
How to store Cetrotide
Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is
stated on the carton, vial and pre-filled syringe after EXP.
The expiry date refers to the last day of that month.
Store in a refrigerator (2°C – 8°C). Do not freeze or place
next to the freezer compartment or a freezer pack.
Store in the original package in order to protect from
light.
The unopened product may be stored in the original
package at room temperature (not above 30°C) for up to
three months.
The solution should be used immediately after preparation.
Do not use this medicine if you notice that the white
powder in the vial has changed in appearance. Do not use
the prepared solution in the vial if it is not clear and
colourless or if it has particles in it.
Do not throw any medicine via wastewater or household
waste. Ask your pharmacist how to throw away medicines
you no longer use. These measures will help to protect the
environment
side Effects
Like all medicines, this medicine can cause side effects,
although not everybody gets them.
Allergic reactions
• Warm, red skin, itching (often in your groin or armpits), red, itchy, raised areas (hives), runny nose, fast or uneven pulse, swelling of your tongue and throat, sneezing, wheezing, or serious difficulty breathing, or dizziness . You may be having a possible serious, life-threatening allergic reaction to the medicine.
This is uncommon (may affect up to 1 in 100 women).
If you notice any of the side effects above, stop using Cetrotide and contact your doctor immediately.
Ovarian Hyper-stimulation Syndrome (OHSS)
This may occur due to the other medicines that you are using to stimulate your ovaries.
• Lower abdominal pain together with feeling sick (nausea) or being sick (vomiting) may be the symptoms of OHSS. This may indicate that the ovaries over-reacted to the treatment and that large ovarian cysts developed. This event is common (may affect up
to 1 in 10 women).
• The OHSS may become severe with clearly enlarged ovaries, decreased urine production, weight gain, difficulty breathing or fluid in your stomach or chest.
This event is uncommon (may affect up to 1 in 100 women).
If you notice any of the side effects above, contact your doctor immediately.
Other side effects
Common (may affect up to 1 in 10 women):
• Mild and short-lasting skin irritation may occur at the injection site like redness, itching, or swelling.
Uncommon (may affect up to 1 in 100 women):
• Feeling sick (nausea)
• Headache.
Reporting of side effects
If you get any side effects, talk to your doctor. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via United Kingdom Yellow Card Scheme
Website: www.mhra.gov.uk/yellowcard
Ingredients
What Cetrotide contains
– The active substance is cetrorelix. Each vial contains 0.25 mg cetrorelix (as acetate).
– The other ingredients are:
• In the powder: mannitol.
• In the solvent: water for injections
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