Side Effects

POSSIBLE SIDE EFFECTS of Co-amoxiclav Tablets

Like all medicines, this medicine can cause side effects, although not everybody gets them. Serious side effects → Contact a doctor immediately if you get any of these symptoms. Allergic reactions (stop taking Co-amoxiclav tablets) • Skin rash • Inflammation of blood vessels (vasculitis) which may be visible as red or purple raised spots on the skin, but can affect other parts of the body • Fever, joint pain, swollen glands in the neck, armpit or groin • Swelling, sometimes of the face or mouth (angioedema), causing difficulty in breathing • Collapse Inflammation of large intestine Inflammation of the large intestine, causing watery diarrhoea usually with blood and mucus, stomach pain and/or fever. • Skin rash, which may blister, and looks like small targets (central dark spots surrounded by a paler area, with a dark ring around the edge – erythema multiforme) • Inflammation of the protective membrane surrounding the brain (aseptic meningitis) • Serious skin reactions: – A widespread rash with blisters and peeling skin, particularly around the mouth, nose, eyes and genitals (Stevens-Johnson syndrome), and a more severe form, causing extensive peeling of the skin (more than 30% of the body surface – toxic epidermal necrolysis) – Widespread red skin rash with small pus-containing blisters (bullous exfoliative dermatitis) – A red, scaly rash with bumps under the skin and blisters (exanthemous pustulosis) – flu-like symptoms with a rash, fever, swollen glands, and abnormal blood test results (including increased white blood cells (eosinophilia) and liver enzymes) (Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)) Other side effects Very common side effects These may affect more than 1 in 10 people • diarrhoea (in adults) Common side effects These may affect up to 1 in 10 people • Thrush (candida – a yeast infection of the vagina, mouth or skin folds) • Feeling sick (nausea), especially when taking high doses → if affected take Co-amoxiclav tablets before food • Vomiting • Diarrhoea (in children) Uncommon side effects These may affect up to 1 in 100 people • skin rash, itching • raised itchy rash (hives) • indigestion • dizziness • headache Uncommon side effects that may show up in your blood tests: • Increase in some substances (enzymes) produced by the liver. Rare side effects These may affect up to 1 in 1000 people Rare side effects that may show up in your blood tests: • Low number of cells involved in blood clotting • Low number of white blood cells. Frequency not known These side effects have occurred in a very small number of people but their exact frequency is unknown. • Inflammation of the liver (hepatitis) • Jaundice, caused by increases in the blood of bilirubin (a substance produced in the liver) which may make your skin and whites of the eyes appear yellow • Inflammation of tubes in the kidney • Blood takes longer to clot • Hyperactivity • Convulsions (in people taking high doses of Co-amoxiclav tablets or who have kidney problems) • Black tongue which looks hairy Side effects that may show up in your blood or urine tests: • Severe reduction in the number of white blood cells • Low number of red blood cells (haemolytic anaemia) • Crystals in urine If you get side effects → Tell your doctor or pharmacist if any of the side effects become severe or troublesome, or if you notice any side effects not listed in this leaflet.

Reporting of side effects If you get any side effects, talk to your doctor or, pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard. By reporting side effects, you can help provide more information on the safety of this medicine.