What DuoTrav Eye Drops is and what it is used for?
DuoTrav eye drop solution is a combination of two active substances travoprost and timolol. Travoprost is a prostaglandin analogue which works by increasing the outflow of aqueous fluid from the eye, which lowers its pressure. Timolol is a beta blocker which works by reducing the production of fluid within the eye. The two substances work together to reduce pressure within the eye. DuoTrav eye drops are used to treat high pressure in the eye in adults, including the elderly. This pressure can lead to an illness called glaucoma
What is Glaucoma?
Glaucoma is a common eye condition where the optic nerve, which connects the eye to the brain, becomes damaged.
It’s usually caused by fluid building up in the front part of the eye, which increases pressure inside the eye.
Your eye contains a clear, watery liquid that feeds the inside of the eye. Liquid is constantly being drained out of the eye and new liquid is made to replace this. If the liquid cannot drain out quickly enough, the pressure inside the eye builds up. This medicine works by increasing the amount of liquid that is drained. This reduces the pressure inside the eye. If the high pressure is not reduced, it could lead to a disease called glaucoma and eventually damage your sight.
Glaucoma can lead to loss of vision if it’s not diagnosed and treated early.
It can affect people of all ages, but is most common in adults in their 70s and 80s.
Glaucoma does not usually cause any symptoms to begin with.
It tends to develop slowly over many years and affects the edges of your vision (peripheral vision) first.
For this reason, many people do not realise they have glaucoma, and it’s often only picked up during a routine eye test.
If you do notice any symptoms, they might include blurred vision, or seeing rainbow-coloured circles around bright lights.
Both eyes are usually affected, although it may be worse in 1 eye.
Very occasionally, glaucoma can develop suddenly and cause:
Visit an opticians or a GP if you have any concerns about your vision.
If you have glaucoma, early diagnosis and treatment can help stop your vision getting worse.
Without treatment, glaucoma can eventually lead to blindness.
If you develop symptoms of glaucoma suddenly, go to your nearest eye casualty unit or A&E as soon as possible.
This is a medical emergency that may require immediate treatment.
There are several different types of glaucoma.
The most common is called primary open angle glaucoma. This tends to develop slowly over many years.
It’s caused by the drainage channels in the eye becoming gradually clogged over time.
Other types of glaucoma include:
acute angle closure glaucoma – an uncommon type caused by the drainage in the eye becoming suddenly blocked, which can raise the pressure inside the eye very quickly
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Order & Collect
Free next-day collection from In-Store
UK Delivery
Standard Delivery within the UK £3.50 Delivery time 3-4 days First Class Delivery within the UK £5.90 Delivery time 1-2 days Priority Delivery within the UK £7.10. Next day delivery by 1pm. Order must be placed by 1pm. Priority delivery is only available Monday to Thursday.
Europe Delivery
Standard Delivery within EEC from £12.50 Delivery time up to 5 days depending on the local delivery service within your country. Expedited Delivery within EEC £39.50 Delivery time 2 days. Delivery by DHL, UPS or TNT.
Rest of the World
Standard Delivery Rest of the World from £16.10 Delivery Time 10 – 15 Days Expedited Delivery Rest of the World £55.09 Delivery 5 days. Delivery service by DHL, TNT or UPS
What you need to know before you use DuoTrav eye drops
Do not use DuoTrav eye drops
• if you are allergic to travoprost, prostaglandins, timolol, beta blockers or any of the other ingredients of this medicine (listed in section 6).
• if you have now or have had in the past respiratory problems such as asthma, severe chronic obstructive bronchitis (severe lung disease which may cause wheeziness, difficulty in breathing
and/or long-standing cough), or other types of breathing problems.
• if you have severe hay fever.
• if you have a slow heartbeat, heart failure or a disorder of heart rhythm (irregular heartbeat).
• if the surface of your eye is cloudy.
Ask your doctor for advice if any of these applies to you.
Warning and precautions
Talk to your doctor before using DuoTrav if you have now or have had in the past
• coronary heart disease (symptoms can include chest pain or tightness, breathlessness or choking), heart failure, low blood pressure.
• disturbances of heart rate such as slow heartbeat.
• breathing problems, asthma or chronic obstructive pulmonary disease.
• poor blood circulation disease (such as Raynaud’s disease or Raynaud’s syndrome).
• diabetes (as timolol may mask signs and symptoms of low blood sugar).
• overactivity of the thyroid gland (as timolol may mask signs and symptoms of thyroid disease).
• myasthenia gravis (chronic neuromuscular weakness).
• cataract surgery.
• eye inflammation.
If you need to have any type of surgery, tell your doctor that you are using DuoTrav as timolol may change the effects of some medicines used during anaesthesia.
If you get any severe allergic reaction (skin rash, redness and itching of the eye) while using DuoTrav, whatever the cause, adrenaline treatment may not be as effective. It is therefore important to tell the doctor that you are using DuoTrav when you are to receive any other treatment.
DuoTrav may change the colour of your iris (the coloured part of your eye). This change may be permanent.
DuoTrav may increase the length, thickness, colour and/or number of your eyelashes and may cause unusual hair growth on your eyelids.
Travoprost may be absorbed through the skin and therefore should not be used by women who are pregnant or are attempting to become pregnant. If any of the medicine comes into contact with the skin then it should be washed off straight away.
Children
DuoTrav is not to be used by children and adolescents under 18 years of age.
Other medicines and DuoTrav
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription.
DuoTrav can affect or be affected by other medicines you are using, including other eye drops for the treatment of glaucoma. Tell your doctor if you are using or intend to use medicines to lower blood
pressure, heart medicines including quinidine (used to treat heart conditions and some types of malaria), medicines to treat diabetes or the antidepressants fluoxetine or paroxetine.
Pregnancy, breast-feeding and fertility
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.
Do not use DuoTrav if you are pregnant unless your doctor considers it necessary. If you could get pregnant you must use adequate contraception whilst you use the medicine.
Do not use DuoTrav if you are breast-feeding. DuoTrav may get into your milk.
Driving and using machines
You may find that your vision is blurred for a time just after you use DuoTrav, DuoTrav may also cause hallucinations, dizziness, nervousness or fatigue in some patients.
Do not drive or use machines until any such symptomshas worn off.
DuoTrav contains hydrogenated castor oil and propylene glycol which may cause skin reactions and irritation.
How to store DuoTrav eye drops
Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the bottle label and carton after EXP.
The expiry date refers to the last day of that month.
Do not store above 30°C.
You must throw away the bottle 4 weeks after you first opened it to prevent the risk of infections.
Each time you start a new bottle write down the date you open it in the spaces on the bottle label and
carton.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to
throw away medicines you longer use. These measures will help protect the environment.
Side Effects
Like all medicines, Duotrav eye drops can cause side effects although not everybody gets them.
You can usually carry on using the drops, unless the effects are serious. If you are worried, talk to a
doctor or pharmacist. Do not stop using DuoTrav without speaking to your doctor.
Very common side effects (may affect more than 1 in 10 people)
Effects in the eye
Eye redness.
Common side effects (may affect up to 1 in 10 people)
Effects in the eye
Eye surface inflammation with surface damage, eye pain, blurred vision, abnormal vision, dry eye,
itchy eye, eye discomfort, signs and symptoms of eye irritation (e.g. burning, stinging).
Uncommon side effects (may affect up to 1 in 100 people)
Effects in the eye
Inflammation of the eye surface, inflammation of the eyelid, swollen conjunctiva, increased growth of
eyelashes, iris inflammation, eye inflammation, sensitivity to light, reduced vision, tired eyes, eye
allergy, eye swelling, increased tear production, eyelid redness, eyelid colour change, skin darkening
(around the eye).
General side effects
Allergic reaction to active substance, dizziness, headache, increased or decreased blood pressure,
shortness of breath, excessive hair growth, drip at back of throat, skin inflammation and itching,
decreased heart rate.
Rare side effects (may affect up to 1 in 1,000 people)
Effects in the eye
Thinning of the eye surface, inflammation of the eyelid glands, broken blood vessel in the eye, eyelid
crusting, abnormally positioned eyelashes, abnormal growth of lashes.
General side effects
Nervousness, irregular heart rate, loss of hair, voice disorders, difficulty breathing, cough, throat
irritation, hives, abnormal liver blood tests, skin discolouration, thirst, tiredness, discomfort inside of
nose, coloured urine, pain in hands and feet.
Not known (frequency cannot be estimated from the available data)
Effects in the eye
Droopy eyelid (making the eye stay half closed), sunken eyes (eyes appear more inset), changes in the
colour of the iris (coloured part of the eye).
General side effects
Rash, heart failure, chest pain, stroke, fainting, depression, asthma, increased heart rate, numbness or
tingling sensation, palpitations, swelling in the lower limbs, bad taste.
Additionally:
DuoTrav is a combination of two active substances, travoprost and timolol. Like other medicines
administered to the eyes, travoprost and timolol (a beta blocker) are absorbed into the blood. This may
cause side effects similar to those seen when beta-blocking medicines that are administered by mouth
or by injection. The incidence of side effects after administration to the eyes is lower than after
5
administration by mouth or by injection.
The side effects listed below include reactions seen with the class of beta blockers used for treating
eye conditions or reactions seen with travoprost alone:
Effects in the eye
Inflammation of the eyelid, inflammation in the cornea, detachment of the layer below the retina that
contains blood vessels following filtration surgery which may cause visual disturbances, decreased
corneal sensitivity, corneal erosion (damage to the front layer of the eyeball), double vision, eye
discharge, swelling around the eye, eyelid itching, outward turning of eyelid with redness, irritation
and excessive tears, blurred vision (sign of clouding of the eye lens), swelling of a section of the eye
(uvea), eczema of the eyelids, halo vision, decreased eye sensation, pigmentation inside the eye,
dilatated pupils, change in eyelash colour, change in the texture of the eyelashes, abnormal field of
vision.
General side effects
Ear and labyrinth disorders: dizziness with spinning sensation, ringing in the ears.
Heart and circulation: slow heart rate, palpitations, oedema (fluid build-up), changes in heartbeat
rhythm or speed, congestive heart failure (heart disease with shortness of breath and swelling of the
feet and legs due to fluid build-up), a type of heart rhythm disorder, heart attack, low blood pressure,
Raynaud’s phenomenon, cold hands and feet, reduced blood supply to the brain.
Respiratory: constriction of the airways in the lungs (predominantly in patients with pre-existing
disease), runny or stuffy nose, sneezing (due to allergy), difficulty breathing, nose bleed, nasal
dryness.
Nervous system and general disorders: difficulty sleeping (insomnia), nightmares, memory loss,
hallucinations, loss of strength and energy, anxiety (excessive emotional distress).
Gastrointestinal: taste disturbances, nausea, indigestion, diarrhoea, dry mouth, abdominal pain,
vomiting and constipation.
Allergy: increased allergic symptoms, generalised allergic reactions including swelling beneath the
skin that can occur in areas such as the face and limbs and can obstruct the airway. which may cause
difficulty swallowing or breathing, localised and generalised rash, itchiness, severe sudden
life-threatening allergic reaction.
Skin: skin rash with white silvery coloured appearance (psoriasiform rash) or worsening of psoriasis,
peeling skin, abnormal hair texture, inflammation of the skin with itchy rash and redness, hair colour
change, loss of eyelashes, itching, abnormal hair growth, skin redness.
Muscular: increases in signs and symptoms of myasthenia gravis (muscle disorder), unusual
sensations like pins and needles, muscle weakness/tiredness, muscle pain not caused by exercise, joint
pain.
Renal and urinary disorders: difficulty and pain when passing urine, involuntary leakage of urine,
Reproduction: sexual dysfunction, decreased libido.
Metabolism: low blood sugar levels, increase in prostate cancer marker.
Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects
not listed in this leaflet. You can also report side effects directly via the national reporting system (see
details below). By reporting side effects you can help provide more information on the safety of this
medicine.
Ingredients
What DuoTrav eye drops contains
– The active substances are travoprost and timolol.
Each mL of solution contains 40 micrograms of travoprost and 5 mg of timolol (as timolol maleate).
– The other ingredients are Polyquaternium-1, mannitol (E421), propylene glycol (E1520), polyoxyethylene hydrogenated castor oil 40, boric acid, sodium chloride, sodium hydroxide or
hydrochloric acid (to adjust pH), purified water.
Tiny amounts of sodium hydroxide or hydrochloric acid are added to keep acidity levels (pH levels) normal.
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