Malarone tablets is used to prevent and treat malaria. It contains two active ingredients, atovaquone and proguanil hydrochloride, which work together to kill the parasites that cause malaria. Malarone can be used to prevent malaria in adults and children who are going to areas where there is a risk of getting the infection. It can also be used to treat malaria in adults and children.
What is Malaria?
Malaria is a serious tropical disease that can be fatal if not treated promptly. A single mosquito bite leads to infection.
It’s important to be aware of the symptoms of malaria if you’re travelling to areas where there’s a high risk of the disease.
Symptoms of malaria can develop as quickly as 7 days after you’re bitten by an infected mosquito.
Typically, the time between being infected and when symptoms start (incubation period) is 7 to 18 days, depending on the specific parasite you’re infected with. However, in some cases it can take up to a year for symptoms to develop.
The initial symptoms of malaria are flu-like and include:
These symptoms are often mild and can sometimes be difficult to identify as malaria.
How to protect yourself from malaria?
People of any age can get malaria. It is a serious disease, but it is preventable. As well as taking Maloff Protect, it is very important that you also take steps to avoid being bitten by mosquitoes. The bite avoidance measures listed below should be used in combination for maximum effectiveness.
Use insect repellent on exposed areas of the skin.
Wear clothing that covers most of the body, especially after sunset as this is the time when mosquitoes are most active.
Sleep in a room with screened windows and doors or under a mosquito net (it is preferable to sleep under a mosquito net treated with insecticide if possible).
Close windows and doors at sunset, if they are not screened.
Sleep in a room with air-conditioning or a fan, as mosquitoes are less active in cooler temperatures.
Consider using an insecticide (mats, spray, plug-ins) to clear a room of insects or to stop mosquitoes from entering the room.
Can someone who is pregnant or breastfeeding use Malarone Tablets?
If you are pregnant, think you may be pregnant or intend to get pregnant, or you are breastfeeding, do not take Maloff Protect unless your doctor tells you to.
Seek advice from your doctor or pharmacist if you are pregnant or breastfeeding and need to take an antimalarial.
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Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.
Take Malarone with food or a milky drink, where possible.
It is best to take Malarone at the same time each day.
If you are sick (vomit)
For preventing malaria:
▪ if you are sick (vomit) within 1 hour of taking your Malarone tablet, take another dose straight away
▪ it is important to take the full course of Malarone. If you have to take extra tablets due to sickness, you may need another prescription.
▪ if you have been vomiting, it is especially important to use extra protection, such as repellents and bednets. Malarone may not be as effective, as the amount absorbed will be reduced. For treating malaria:
▪ if you have vomiting and diarrhoea tell your doctor, you will need regular blood tests.
Malarone will not be as effective, as the amount absorbed will be reduced. The tests will check whether the malaria parasite is being cleared from your blood.
To prevent malaria
The recommended usual dose for adults is 1 tablet once a day, taken as below.
Not recommended for preventing malaria in children, or in adults who weigh less than 40 kgs.
Malarone paediatric tablets are recommended for preventing malaria in adults and children who weigh
less than 40 kgs.
To prevent malaria in adults:
▪ start taking Malarone 1 to 2 days before travelling to an area which has malaria
▪ continue taking it every day during your stay
▪ continue taking it for another 7 days after your return to a malaria-free area.
To treat malaria
The recommended dose for adults is 4 tablets once a day for 3 days.
For children the dose depends on their bodyweight:
▪ 11-20 kg – 1 tablet once a day for 3 days
▪ 21-30 kg – 2 tablets once a day for 3 days
▪ 31-40 kg – 3 tablets once a day for 3 days
▪ over 40 kg – dose as for adults.
Not recommended for treating malaria in children who weigh less than 11 kgs.
For children who weigh less than 11 kgs talk to your doctor. There may be a different type of Malarone tablet available in your country.
Delivery Options
Delivery options
All deliveries are subject to the availability of the product and product sale conditions been met.
Order & Collect
Free next-day collection from In-Store
UK Delivery
Standard Delivery within the UK £3.50 Delivery time 3-4 days First Class Delivery within the UK £5.90 Delivery time 1-2 days Priority Delivery within the UK £7.10. Next day delivery by 1pm. Order must be placed by 1pm. Priority delivery is only available Monday to Thursday.
Europe Delivery
Standard Delivery within EEC from £12.50 Delivery time up to 5 days depending on the local delivery service within your country. Expedited Delivery within EEC £39.50 Delivery time 2 days. Delivery by DHL, UPS or TNT.
Rest of the World
Standard Delivery Rest of the World from £16.10 Delivery Time 10 – 15 Days Expedited Delivery Rest of the World £55.09 Delivery 5 days. Delivery service by DHL, TNT or UPS
Do not take Malarone:
▪ if you are allergic to atovaquone, proguanil hydrochloride or any of the ingredients of this medicine
▪ for preventing malaria, if you have severe kidney disease.
→ Tell your doctor if either of these apply to you.
Take special care with Malarone
Talk to your doctor or pharmacist before taking Malarone if:
▪ you have severe kidney disease
▪ your child is being treated for Malaria and weighs less than 11 kg. There is another tablet strength to treat children who weigh less than 11 kg
→ Tell your doctor or pharmacist if any of these applies to you.
Other medicines and Malarone
Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including medicines you’ve bought without a prescription.
Some medicines can affect the way Malarone works, or Malarone itself can strengthen or weaken the effectiveness of other medicines taken at the same time. These include:
▪ metoclopramide, used to treat nausea and vomiting
▪ the antibiotics, tetracycline, rifampicin and rifabutin
▪ efavirenz or certain highly active protease-inhibitors used to treat HIV
▪ warfarin and other medicines that stop blood clotting
▪ etoposide used to treat cancer.
→ Tell your doctor if you are taking any of these. Your doctor may decide that Malarone isn’t suitable for you, or that you need extra check ups while you’re taking it.
→ Remember to tell your doctor if you start taking any other medicines while you’re taking
Malarone.
Malarone with food and drink
Take Malarone with food or a milky drink, where possible. This will increase the amount of Malarone your body can absorb, and make your treatment more effective. Pregnancy and breast-feeding
If you are pregnant, do not take Malarone unless your doctor recommends it.
→ Ask your doctor or pharmacist for advice before taking Malarone
Do not breast-feed while taking Malarone, as the ingredients of Malarone may pass into breast milk and may harm your baby. Driving and using machines
If you feel dizzy, do not drive.
Malarone makes some people feel dizzy. If this happens to you, do not drive, use machines or take part in activities where you may put yourself or others at risk.
Malarone contains sodium
This medicine contains less than 1 mmol sodium (23 mg) per tablet, that is to say essentially ‘sodium free’
Side Effects
Malarone Tablets Side Effects
Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Look out for the following severe reactions. They have occurred in a small number of people, but their exact frequency is unknown.
Severe allergic reactions – signs include:
▪ rash and itching
▪ sudden wheezing, tightness of the chest or throat, or difficulty breathing
▪ swollen eyelids, face, lips, tongue or other part of the body.
→ Contact a doctor immediately if you get any of these symptoms. Stop taking Malarone.
Severe skin reactions
▪ skin rash, which may blister and looks like small targets (central dark spots, surrounded by paler area with a dark ring around the edge) (erythema multiforme)
▪ severe widespread rash with blisters and peeling skin, particularly occurring around the mouth, nose, eyes and genitals (Stevens-Johnson syndrome).
→ If you notice any of these symptoms contact a doctor urgently.
Most of the other side effects reported have been mild and have not lasted very long.
Very common side effects
These may affect more than 1 in 10 people:
▪ headache
▪ feeling sick and being sick (nausea and vomiting)
▪ stomach pain
▪ diarrhoea.
Common side effects
These may affect up to 1 in 10 people:
▪ dizziness
▪ sleeping problems (insomnia)
▪ strange dreams
▪ depression
▪ loss of appetite
▪ fever
▪ rash which may be itchy
▪ cough
Common side effects, which may show up in your blood tests are:
▪ reduced numbers of red blood cells (anaemia) which can cause tiredness, headaches and shortness of breath
▪ reduced numbers of white blood cells (neutropenia) which may make you more likely to catch infections
▪ low levels of sodium in the blood (hyponatraemia)
▪ an increase in liver enzymes.
Uncommon side effects
These may affect up to 1 in 100 people:
▪ anxiety
▪ an unusual awareness of abnormal beating of the heart (palpitations)
▪ swelling and redness of the mouth
▪ hair loss
▪ itchy, bumpy rash (hives).
Uncommon side effects that may show up in your blood tests:
▪ an increase in amylase (an enzyme produced in the pancreas).
Rare side effects
These may affect up to 1 in 1,000 people:
▪ seeing or hearing things that are not there (hallucinations)
Other side effects
Other side effects have occurred in a small number of people but their exact frequency is unknown.
▪ Inflammation of the liver(hepatitis)
▪ blockage of the bile ducts (cholestatis)
▪ increase in heart rate (tachycardia)
▪ inflammation of the blood vessels (vasculitis) which may be visible as red or purple raised spots
on the skin but can affect other parts of the body
6
▪ fits (seizures)
▪ panic attacks, crying
▪ nightmares
▪ severe mental health problem in which the person loses contact with reality and is unable to think
and judge clearly
▪ indigestion
▪ mouth ulcers
▪ blisters
▪ peeling skin
▪ increased sensitivity of the skin to sunlight.
Other side effects that may show up in your blood tests:
▪ A decrease in all types of blood cells (pancytopenia).
Reporting of side effects
If you get any side effects talk to your doctor or pharmacist. This includes any possible side effects
not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at:
www.mhra.gov.uk/yellowcard.
Ingredients
Malarone Tablets Ingredients
The active ingredients are: 250 mg of atovaquone and 100 mg of proguanil hydrochloride in each tablet.
The other ingredients are:
tablet core: poloxamer 188, microcrystalline cellulose, hydroxypropyl cellulose, povidone K30,
sodium starch glycollate (Type A), magnesium stearate
tablet coating: hypromellose, titanium dioxide (E171), iron oxide red (E172), macrogol 400 and
polyethylene glycol 8000
Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the carton after EXP. The expiry
date refers to the last day of that month.
Malarone does not require any special storage conditions.
Do not throw away any medicines via waste water or household waste. Ask your pharmacist how to
throw away medicines you no longer use. This will help protect the environment.
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