Menopur 600iu Vial is a gonadotrophin that helps the reproductive organs to work normally in both males and females. Highly purified and containing the active substance menotrophin, Menopur 600iu Vial can help stimulate ovulation in women who are struggling to conceive.
What Menopur 600iu Vial is
Menopur 600iu Vial contains the active substance menotrophin which belongs to a group of medicines called gonadotrophins. Menotrophin is a highly purified mixture of two hormones called follicle stimulating hormone (FSH) and luteinizing hormone (LH). FSH and LH are natural hormones produced in both males and females. They help the reproductive organs to work normally. The FSH and LH in Menopur are obtained from the urine of
postmenopausal women.
What Menopur 600iu Vial is used for
In women, MENOPUR is used to treat infertility in the following two situations:
• To promote the release of eggs from the ovaries (ovulation) in women who are not ovulating including with polycystic ovarian disease and who have not responded to treatment with another medicine called clomiphene citrate.
• To help multiple follicles and therefore eggs to develop in women having in vitro fertilisation (IVF) treatment or other
types of ‘assisted conception’. The eggs are then harvested and fertilised outside the body.
In men, MENOPUR is used to treat infertility in the following situation:
• Low sperm count (oligospermia).
What is Infertility
Infertility is when a couple cannot get pregnant (conceive) despite having regular unprotected sex.
Around 1 in 7 couples may have difficulty conceiving.
About 84% of couples will conceive naturally within a year if they have regular unprotected sex (every 2 or 3 days).
For couples who have been trying to conceive for more than 3 years without success, the likelihood of getting pregnant naturally within the next year is 1 in 4, or less.
Some people get pregnant quickly, but for others it can take longer. It’s a good idea to see a GP if you have not conceived after a year of trying.
Women aged 36 and over, and anyone who’s already aware they may have fertility problems, should see their GP sooner.
surgical procedures such as treatment for endometriosis, repair of the fallopian tubes, or removal of scarring (adhesions) within the womb or abdominal cavity
Some treatments for infertility, such as IVF, can cause complications.
For example:
multiple pregnancy – if more than 1 embryo is placed in the womb as part of IVF treatment there’s an increased chance of having twins; this may not seem like a bad thing, but it significantly increases the risk of complications for you and your babies
ectopic pregnancy – the risk of having an ectopic pregnancy is slightly increased if you have IVF
There are many possible causes of infertility, and fertility problems can affect either partner. But in a quarter of cases it is not possible to identify the cause.
Common causes of infertility include:
lack of regular ovulation (the monthly release of an egg)
poor quality semen
blocked or damaged fallopian tubes
endometriosis – where tissue that behaves like the lining of the womb (the endometrium) is found outside the womb
RISK FACTORS
There are also several factors that can affect fertility.
These include:
age – fertility declines with age
weight – being overweight or obese (having a BMI of 30 or over) reduces fertility; in women, being overweight or severely underweight can affect ovulation
sexually transmitted infections (STIs) – several STIs, including chlamydia, can affect fertility
smoking – can affect fertility: smoking (including passive smoking) affects your chance of conceiving and can reduce semen quality; read more about quitting smoking
alcohol – the safest approach is not to drink alcohol at all to keep risks to your baby to a minimum. Drinking too much alcohol can also affect the quality of sperm (the chief medical officers for the UK recommend adults should drink no more than 14 units of alcohol a week, which should be spread evenly over 3 days or more)
environmental factors – exposure to certain pesticides, solvents and metals has been shown to affect fertility, particularly in men
stress – can affect your relationship with your partner and cause a loss of sex drive; in severe cases, stress may also affect ovulation and sperm production
There’s no evidence to suggest caffeinated drinks, such as tea, coffee and colas, are associated with fertility problems.
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Using Menopur 600
• You will have Menopur as an injection under the skin or into
a muscle.
• You will either be given Menopur by a doctor or nurse or you
will be taught how to give it to yourself.
• Menopur comes as a dry powder in small bottles (vials).
• Once the dry powder has been mixed with the solvent provided,
it should be used straight away.
The dose and length of your treatment
• The dose, and how long your treatment lasts, depends on why
you are using Menopur and how well it works.
• Your doctor or nurse will monitor how you respond to your
treatment.
• This will help them to work out what dose you need and how
long you need to use Menopur for.
In women:
Infertility (to help follicles to mature):
• If you are having periods, your treatment will start within the
first 7 days of your menstrual cycle.
• You may use Menopur daily for up to 3 weeks.
• Or, you may use Menopur every other day for 6 days (three
doses in total).
‘Assisted conception’ such as IVF:
• The usual dose is 75 to 300 IU each day.
• Your doctor will decide how long you need to use Menopur for
In men:
For low sperm count:
• The usual dose is 75 or 150 IU two or three times a week.
• Treatment is normally continued for at least 3 or 4 months
Delivery Options
Delivery options
All deliveries are subject to the availability of the product and product sale conditions been met.
Order & Collect
Free next-day collection from In-Store
UK Delivery
Standard Delivery within the UK £3.50 Delivery time 3-4 days First Class Delivery within the UK £5.90 Delivery time 1-2 days Priority Delivery within the UK £7.10. Next day delivery by 1pm. Order must be placed by 1pm. Priority delivery is only available Monday to Thursday.
Europe Delivery
Standard Delivery within EEC from £12.50 Delivery time up to 5 days depending on the local delivery service within your country. Expedited Delivery within EEC £39.50 Delivery time 2 days. Delivery by DHL, UPS or TNT.
Rest of the World
Standard Delivery Rest of the World from £16.10 Delivery Time 10 – 15 Days Expedited Delivery Rest of the World £55.09 Delivery 5 days. Delivery service by DHL, TNT or UPS
Do not use Menopur if:
• You are allergic (hypersensitive) to menotrophin or any of the
other ingredients of Menopur (listed in Section 6).
• You have a tumour in your pituitary gland (a gland located on
the base of the brain which produces certain hormones,
including growth hormones).
• You have a tumour in a part of your brain called the
hypothalamus (part of the brain which controls the conditions
within your body including body temperature and blood
pressure).
• You have high levels of a hormone called prolactin
(hyperprolactinaemia)
Also, if you are a woman do not use Menopur if:
• You have tumours of your womb (uterus), ovaries or breasts.
• You have cysts on your ovaries or enlarged ovaries that are not due
to polycystic ovary syndrome (a condition that prevents eggs from
being released from the ovaries).
• You have bleeding from your vagina for an unknown reason.
• You have primary ovarian failure (a condition in which the ovaries
do not function properly).
• You have blocked fallopian tubes, unless you are having IVF
or ICSI (intracytoplasmic sperm injection).
• You are having an early (premature) menopause.
• You have certain physical problems in your reproductive
organs (womb, fallopian tubes, ovaries or cervix).
• Your womb has been removed (hysterectomy).
• You have fibroid tumours (tumours in your womb that are not
cancer).
• You are pregnant or breast-feeding
Side effects that can happen in women:
If you notice any of the following signs, tell your doctor
straight away. It may mean that your ovaries have been
stimulated too much and you may need urgent medical
treatment. This side effect is common (affects less than 1 in
10 people).
• Feeling sick
• Being sick
• Diarrhoea
• Pain or swelling of the tummy
• Weight gain
• Difficulty breathing
• Feeling more thirsty than usual
• Producing less urine when you go to the toilet or going to the
toilet less often
If you notice any of the above signs, tell your doctor straight
away.
If treatment with Menopur results in pregnancy
The following are more likely to happen in women who have
had fertility treatment than in women who have got pregnant
(conceived) naturally:
• Being pregnant with more than one baby. This carries an
increased risk of problems for the mother during the
pregnancy and at or around the time of birth.
• The fertilised egg implanting outside the womb (ectopic
pregnancy). This is more likely if you have had tubal
disease in the past (a condition where the fallopian tubes are
blocked or damaged).
• Miscarriage or abortion.
• A slightly higher risk of your baby being born with physical
defects.
Your doctor will be able to discuss this with you before you
start treatment.
Side effects that can happen in both women and men:
Common (affects less than 1 in 10 people):
• Headache
• Feeling sick (nausea)
• Being sick (vomiting)
• Pain or swelling of the tummy (abdomen)
• Pain or inflammation where the injection was given
Uncommon (affects less than 1 in 100 people):
• Blood clots in the veins, usually of the leg (deep vein
thrombosis)
Very rare (affects less than 1 in 10,000 people):
• Allergic reactions
• If Menopur is used for a long time, your body may make
antibodies which can stop the treatment from working
• Keep out of the reach and sight of children.
• Do not use Menopur after the expiry date which is stated on
the carton. The expiry date refers to the last day of that
month.
• Store below 25°C.
• Store in the original container to protect from light.
• Do not freeze before or after reconstitution.
• Medicines should not be disposed of via wastewater or
household waste. Ask your pharmacist how to dispose of
medicines no longer required. These measures will help to
protect the environment.
What Menopur looks like and contents of the pack
How to store MENOPUR
• Keep out of the sight and reach of children.
• Do not use MENOPUR after the expiry date which is stated
on the packaging. The expiry date refers to the last day of that
month.
• For immediate and single use following reconstitution.
• Do not store above 25°C. Do not freeze.
• Store in the original package in order to protect from light.
• Medicines should not be disposed of via wastewater or
household waste. Ask your pharmacist how to dispose of
medicines no longer required. These measures will help to
protect the environment
Side Effects
Like all medicines, MENOPUR can cause side effects, although not everybody gets them. Side effects that can happen in women: If you notice any of the following signs, tell your doctor immediately. It may mean that your ovaries have been stimulated too much Ovarian Hyperstimulation Syndrome (OHSS), especially in women with polycystic ovaries and you may need urgent medical treatment. Symptoms include: • Nausea (feeling sick) • Vomiting (being sick) • Diarrhoea. • Weight gain. • Pain or swelling of the stomach In cases of severe OHSS: • Fluid build-up in the stomach, pelvis and/or chest • Difficulty in breathing. • Decreased urination (producing less urine when you go to the toilet or going to the toilet less often). • Formation of blood clots in blood vessels (thromboembolism) • Twisting of ovaries (ovarian torsion) If you notice any of the above signs, tell your doctor immediately. Side effects that can happen in both women and men: STOP USING MENOPUR if you experience allergic (hypersensitivity) reactions including; skin rashes, itching, swelling of the face, lips or throat and difficulty in breathing. If you experience any of these rare side effects, you should contact your doctor or go to the nearest hospital immediately. Common (may affect up to 1 in 10 people): • Pain or swelling of the stomach • Headache • Nausea • Pelvic pain • Overstimulation of the ovaries resulting into high levels of activity (OHSS) • Pain or inflammation at the injection site (redness, bruising, swelling and/or itching) Uncommon (may affect up to 1 in 100 people): • Vomiting • Discomfort in stomach • Diarrhoea • Fatigue • Dizziness • Sacs of fluid within ovaries (ovarian cysts) • Breast complaints (include breast pain, breast tenderness, breast discomfort, nipple pain and breast swelling) • Hot flush Rare (may affect up to 1 in 1,000 people) • Acne • Rash Unknown (the frequency of these reported side effects is not known) • Eyesight disturbances • Allergic reactions • Pain in muscle and joint (e.g. back pain, neck pain and pain in arms and legs) • Twisting of ovary (ovarian torsion) as a complication of OHSS • Itching • Hives Reporting of side effects If you get any side effects, talk to your doctor, nurse or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme, website: www.mhra.gov.uk/yellowcard. By reporting side effects you can help provide more information on the safety of this medicine
Ingredients
What MENOPUR 600iu contains
• MENOPUR is a sterile freeze dried powder for injection. The
active substance is Highly Purified Menotrophin. Each vial
contains 600IU of the active substance, corresponding
to 600IU of FSH activitiy and 600IU of LH activity. After
reconstitution, 1ml of the reconstituted solution contains
600IU of Highly Purified Menotrophin.
• The other ingredients for powder are Lactose monohydrate,
Polysorbate 20, Sodium phosphate dibasic heptahydrate and
Phosphoric acid (concentrated).
• The solvent contains Metacresol and Water for injection.
What MENOPUR looks like and contents of the pack
MENOPUR is a powder and solvent for solution for injection.
Supplied as a pack of 1 clear glass vial containing white to
off-white lyophilised powder, 1 pre-filled syringe with colourless
solvent for reconstitution, 1 needle for reconstitution, 9 alcohol
pads and 9 disposable syringes for administration graduated in
FSH/LH units with pre-fixed needles
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Urinary or genital infections caused by a parasite, Trichomonas
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