Side Effects

Possible side effects of omeprazole injection

Like all medicines, this medicine can cause side effects, although not everybody gets them. If you notice any of the following rare but serious side effects, stop using Omeprazole and contact a doctor immediately: • Sudden wheezing, swelling of your lips, tongue and throat or body, rash, fainting or difficulties in swallowing (severe allergic reaction). • Reddening of the skin with blisters or peeling. There may also be severe blisters and bleeding in the lips, eyes, mouth, nose and genitals. This could be ‘Stevens-Johnson syndrome’ or ‘toxic epidermal necrolysis’. • Yellow skin, dark urine and tiredness which can be symptoms of liver problems. Other side effects include: Common side effects (may affect up to 1 in 10 people) • Headache. • Effects on your stomach or gut: diarrhoea, stomach pain, constipation, wind (flatulence). • Feeling sick (nausea) or being sick (vomiting). • Benign polyps in the stomach. Uncommon side effects (may affect up to 1 in 100 people) • Swelling of the feet and ankles. • Disturbed sleep (insomnia). • Dizziness, tingling feelings such as “pins and needles”, feeling sleepy. • Spinning feeling (vertigo). • Changes in blood tests that check how the liver is working. • Skin rash, lumpy rash (hives) and itchy skin. • Generally feeling unwell and lacking energy. Rare side effects (may affect up to 1 in 1000 people) • Blood problems such as a reduced number of white cells or platelets. This can cause weakness, bruising or make infections more likely. • Allergic reactions, sometimes very severe, including swelling of the lips, tongue and throat, fever, wheezing. • Low levels of sodium in the blood. This may cause weakness, being sick (vomiting) and cramps. • Feeling agitated, confused or depressed. • Taste changes. • Eyesight problems such as blurred vision. • Suddenly feeling wheezy or short of breath (bronchospasm). • Dry mouth. • An inflammation of the inside of the mouth. • An infection called “thrush” which can affect the gut and is caused by a fungus. • Liver problems, including jaundice which can cause yellow skin, dark urine, and tiredness. • Hair loss (alopecia). • Skin rash on exposure to sunshine. • Joint pains (arthralgia) or muscle pains (myalgia). • Severe kidney problems (interstitial nephritis). • Increased sweating. Very rare side effects (may affect up to 1 in 10 000 people) • Changes in blood count including agranulocytosis (lack of white blood cells). • Aggression. • Seeing, feeling or hearing things that are not there (hallucinations). • Severe liver problems leading to liver failure and inflammation of the brain. • Sudden onset of a severe rash or blistering or peeling skin. This may be associated with a high fever and joint pains (Erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis) • Muscle weakness. • Enlarged breasts in men. Side effects with unknown frequency (frequency cannot be estimated from the available data) • Inflammation in the gut (leading to diarrhoea). • If you are on Omeprazole for more than three months it is possible that the levels of magnesium in your blood may fall. Low levels of magnesium can be seen as fatigue, involuntary muscle contractions, disorientation, convulsions, dizziness or increased heart rate. If you get any of these symptoms, please tell your doctor promptly. Low levels of magnesium can also lead to a reduction in potassium or calcium levels in the blood. Your doctor may decide to perform regular blood tests to monitor your levels of magnesium. • Rash, possibly with pain in the joints Irreversible visual impairment has been reported in isolated cases of critically ill patients who have received omeprazole intravenous injection, especially at high doses, but no causal relationship has been established. Omeprazole may in very rare cases affect the white blood cells leading to immune deficiency. If you have an infection with symptoms such as fever with a severely reduced general condition or fever with symptoms of a local infection such as pain in the neck, throat or mouth or difficulties in urinating, you must consult your doctor as soon as possible so that a lack of white blood cells (agranulocytosis) can be ruled out by a blood test. It is important for you to give information about your medicine at this time. Do not be concerned by this list of possible side effects. You may not get any of them. Reporting of side effects If you get any side effects talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard or search for MHRA Yellow card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.