Discover the powerful relief offered by Simbrinza Eye Drops, the essential solution for managing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Each 5ml bottle contains a potent combination of Brinzolamide and Brimonidine, two active ingredients that work together to effectively reduce intraocular pressure. This dual-action formula is designed to target different pathways to ensure optimal pressure control and protect your vision.
Simbrinza Eye Drops provides a comprehensive approach to glaucoma treatment, offering the convenience of a single bottle with two powerful medications. Trusted by healthcare professionals, Simbrinza is a reliable and effective choice for maintaining healthy eye pressure and preventing further damage to your vision.
Product Benefits:
Effective Pressure Reduction: Combines Brinzolamide and Brimonidine to significantly lower intraocular pressure in patients with glaucoma or ocular hypertension.
Dual-Action Formula: Targets fluid production and increases fluid outflow for comprehensive intraocular pressure management.
Convenient Application: Available in a 5ml dropper bottle for easy and precise administration.
Trusted Treatment: Recommended by healthcare professionals for its efficacy and safety in managing glaucoma.
Clinically Proven: Meets rigorous MHRA standards, providing confidence in your eye care regimen.
Usage Instructions:
Dosage: Apply one drop in the affected eye(s) twice daily, or as directed by your healthcare provider.
Administration:
Wash your hands thoroughly before use.
Shake the bottle well before each use.
Tilt your head back and pull down the lower eyelid to create a small pocket.
Hold the dropper above the eye and squeeze one drop into the pocket.
Close your eyes and press the inner corner of your eye for 1-2 minutes to prevent the liquid from draining away.
Repeat in the other eye if prescribed.
Precautions:
Do not touch the dropper tip to any surface, including your eye, to avoid contamination.
Replace the cap immediately after use.
If you wear contact lenses, remove them before applying the drops and wait at least 15 minutes before reinserting.
Store the bottle in a cool, dry place away from light.
When it comes to managing elevated intraocular pressure and glaucoma, you need a treatment that is both effective and reliable. Simbrinza Eye Drops provide a powerful dual-action formula that combines Brinzolamide and Brimonidine to significantly lower eye pressure. This clinically proven medication is trusted by healthcare professionals and offers the convenience of a single bottle with two potent ingredients. Order now from our online pharmacy and take the first step towards better eye health with Simbrinza.
What is Glaucoma?
Glaucoma is a common eye condition where the optic nerve, which connects the eye to the brain, becomes damaged.
It’s usually caused by fluid building up in the front part of the eye, which increases pressure inside the eye.
Your eye contains a clear, watery liquid that feeds the inside of the eye. Liquid is constantly being drained out of the eye and new liquid is made to replace this. If the liquid cannot drain out quickly enough, the pressure inside the eye builds up. This medicine works by increasing the amount of liquid that is drained. This reduces the pressure inside the eye. If the high pressure is not reduced, it could lead to a disease called glaucoma and eventually damage your sight.
Glaucoma can lead to loss of vision if it’s not diagnosed and treated early.
It can affect people of all ages, but is most common in adults in their 70s and 80s.
Glaucoma does not usually cause any symptoms to begin with.
It tends to develop slowly over many years and affects the edges of your vision (peripheral vision) first.
For this reason, many people do not realise they have glaucoma, and it’s often only picked up during a routine eye test.
If you do notice any symptoms, they might include blurred vision, or seeing rainbow-coloured circles around bright lights.
Both eyes are usually affected, although it may be worse in 1 eye.
Very occasionally, glaucoma can develop suddenly and cause:
Visit an opticians or a GP if you have any concerns about your vision.
If you have glaucoma, early diagnosis and treatment can help stop your vision getting worse.
Without treatment, glaucoma can eventually lead to blindness.
If you develop symptoms of glaucoma suddenly, go to your nearest eye casualty unit or A&E as soon as possible.
This is a medical emergency that may require immediate treatment.
There are several different types of glaucoma.
The most common is called primary open angle glaucoma. This tends to develop slowly over many years.
It’s caused by the drainage channels in the eye becoming gradually clogged over time.
Other types of glaucoma include:
acute angle closure glaucoma – an uncommon type caused by the drainage in the eye becoming suddenly blocked, which can raise the pressure inside the eye very quickly
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How to use SIMBRINZA EYE DROPS
Always use this medicine exactly as your doctor, optometrist (optician) or pharmacist has told you.
Check with your doctor, optometrist (optician) or pharmacist if you are not sure.
Only use SIMBRINZA for your eyes. Do not swallow or inject.
The recommended dose is one drop in the affected eye or eyes two times a day. Use at the same time
each day.
How to use
Wash your hands before you start
Shake well before use.
Twist off the bottle cap. After the cap is removed, if the tamper evident snap collar is loose, remove it before using the medicine.
Do not touch the dropper with your fingers when opening or closing the bottle. It could infect the drops.
Hold the bottle, pointing down, between your thumb and fingers.
Tilt your head back.
Pull down your lower eyelid with a clean finger, until there is a ‘pocket’ between the eyelid and your eye. The drop will go in here (picture 1).
Bring the bottle tip close to the eye. Do this in front of a mirror if it helps.
Do not touch your eye or eyelid, surrounding areas or other surfaces with the dropper. It could infect the drops.
Gently press on the base of the bottle to release one drop of SIMBRINZA.
Do not squeeze the bottle: it is designed so that a gentle press on the bottom is all that it needs (picture 2).
To reduce the amount of medicine that could come into the rest of the body after application of the eye drop, close your eye and apply gentle pressure to the corner of the eye next to the nose with a finger for at least 2 minutes
If you use drops in both eyes, repeat the steps for your other eye. It is not necessary to close and
shake the bottle before you apply the drop in your other eye. Close the bottle cap firmly immediately
after use.
If you are using other eye drops as well as SIMBRINZA, wait at least five minutes between using
SIMBRINZA and the other drops.
If a drop misses your eye, try again.
If you use more SIMBRINZA than you should
Rinse your eye with warm water. Do not put in any more drops until it is time for your next regular
dose.
Adults who accidentally swallowed medicines containing brimonidine experienced a decreased heart
rate, decreased blood pressure which may be followed by increased blood pressure, heart failure,
difficulty breathing and effects in the nervous system. Should this happen, contact your doctor
immediately.
Serious side effects have been reported in children who accidently swallowed medicines containing
brimonidine. Signs included sleepiness, floppiness, low body temperature, paleness and breathing
difficulties. Should this happen, contact your doctor immediately.
If SIMBRINZA has been accidentally swallowed then you should contact your doctor immediately.
If you forget to use SIMBRINZA
Continue with the next dose as planned. Do not use a double dose to make up for a forgotten dose. Do
not use more than one drop in the affected eye(s) two times a day.
If you stop using SIMBRINZA
Do not stop using SIMBRINZA without first speaking to your doctor. If you stop using SIMBRINZA
the pressure in your eye will not be controlled, which could lead to loss of sight.
If you have any further questions on the use of this medicine, ask your doctor, optometrist (optician) or pharmacist.
Delivery Options
Delivery options
All deliveries are subject to the availability of the product and product sale conditions been met.
Order & Collect
Free next-day collection from In-Store
UK Delivery
Standard Delivery within the UK £3.50 Delivery time 3-4 days First Class Delivery within the UK £5.90 Delivery time 1-2 days Priority Delivery within the UK £7.10. Next day delivery by 1pm. Order must be placed by 1pm. Priority delivery is only available Monday to Thursday.
Europe Delivery
Standard Delivery within EEC from £12.50 Delivery time up to 5 days depending on the local delivery service within your country. Expedited Delivery within EEC £39.50 Delivery time 2 days. Delivery by DHL, UPS or TNT.
Rest of the World
Standard Delivery Rest of the World from £16.10 Delivery Time 10 – 15 Days Expedited Delivery Rest of the World £55.09 Delivery 5 days. Delivery service by DHL, TNT or UPS
What you need to know before you use SIMBRINZA eye drops
Do not use SIMBRINZA
– if you are allergic to brinzolamide or brimonidine tartrate or any of the other ingredients of this medicine (listed in section 6)
– if you are allergic to sulphonamides (examples include medicines used to treat diabetes and infections and also diuretics (water tablets))
– if you are taking a monoamine oxidase (MAO) inhibitors (examples include medicines to treat depression or Parkinson’s disease) or certain antidepressants. You must inform your doctor if
you are taking any antidepressant medicines
– if you have severe kidney problems
– if you have too much acidity in your blood (a condition called hyperchloraemic acidosis)
– in babies and infants aged less than 2 years.
Warnings and precautions
Talk to your doctor, optometrist (optician) or pharmacist before using SIMBRINZA if you have now or have had in the past:
– liver problems
– a type of high pressure in the eyes called narrow-angle glaucoma
– dry eyes or cornea problems
– coronary heart disease (symptoms can include chest pain or tightness, breathlessness or choking), heart failure, high or low blood pressure
– depression
– disturbed or poor blood circulation (such as Raynaud’s disease, Raynaud’s syndrome or cerebral insufficiency).
If you wear soft contact lenses, do not use the drops with your lenses in. See section “Wearing contact
lenses – SIMBRINZA contains benzalkonium chloride” below).
Children and adolescents
SIMBRINZA is not intended for use by children and adolescents aged below 18 years because it has not been studied in this age group. It is particularly important that the medicine is not used in children under the age of 2 years (see section ‘Do not use SIMBRINZA’ above) because it is unlikely to be safe.
Other medicines and SIMBRINZA
Tell your doctor, optometrist (optician) or pharmacist if you are using, have recently used, or might use any other medicines.
SIMBRINZA can affect or be affected by other medicines you are using, including other eye drops for the treatment of glaucoma.
Tell your doctor if you are taking or intend to take any of the following medicines:
– medicines to lower blood pressure
– heart medicines including digoxin (used to treat heart conditions)
– other medicines for glaucoma that also treat altitude sickness known as acetazolamide, methazolamide and dorzolamide
– medicines that can affect the metabolism, such as chlorpromazine, methylphenidate and reserpine
– antiviral, antiretroviral (used to treat Human Immunodeficiency Virus (HIV)) or antibiotic medicines
– antiyeast or antifungal medicines
– monoamine oxidase (MAO) inhibitors, or antidepressants including amitriptyline, nortriptyline, clomipramine, mianserin, venlafaxine and duloxetine
– anaesthetics
– sedatives, opiates, or barbiturates
You should also tell your doctor if the dose of any of your current medicines is changed.
SIMBRINZA with alcohol
If you regularly consume alcohol, ask your doctor, optometrist (optician) or pharmacist for advice before taking this medicine. SIMBRINZA can be affected by alcohol.
Pregnancy and breast-feeding
If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor, optometrist (optician) or pharmacist for advice before taking this medicine. Women who may become
pregnant are advised to use effective contraception during SIMBRINZA treatment. The use of SIMBRINZA is not recommended during pregnancy. Do not use SIMBRINZA unless clearly indicated by your doctor.
If you are breast-feeding, SIMBRINZA may pass into your milk. The use of SIMBRINZA is not recommended during breast-feeding.
Driving and using machines
You may find that your vision is blurred or abnormal for a time just after using SIMBRINZA. SIMBRINZA may also cause dizziness, drowsiness or tiredness in some patients.
3
Do not drive or use machines until the symptoms are cleared.
Wearing contact lenses – SIMBRINZA contains benzalkonium chloride
This medicine contains 0.15 mg benzalkonium chloride in each 5 ml, which is equivalent to 0.03 mg/ml.
Benzalkonium chloride may be absorbed by soft contact lenses and may change the colour of the contact lenses. You should remove contact lenses before using this medicine and put them back
15 minutes afterwards. Benzalkonium chloride may also cause eye irritation, especially if you have dry eyes or a disorder of the cornea (the clear layer at the front of the eye). If you feel abnormal eye sensation, stinging or pain in the eye after using this medicine, talk to your doctor.
How to store SIMBRINZA EYE DROPS
Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the bottle and the carton after “EXP”.
The expiry date refers to the last day of that month.
This medicine does not require any special storage conditions.
Throw away the bottle 4 weeks after first opening to prevent infections and use a new bottle. Write
down the date of opening on the carton in the space provided.
Side Effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
If you experience any of the following side effects, please stop using this medicine and seek immediate medical attention as these could be signs of a reaction to the medicine. The frequency of an allergic
reaction to the medicine is not known (frequency cannot be estimated from the available data).
• Severe skin reactions, including rash or redness or itching on your body or eyes
• Trouble breathing
• Chest pain, irregular heart beat
Contact your doctor immediately if you develop extreme tiredness or dizziness.
The following side effects have been observed with SIMBRINZA and other medicines containing brinzolamide or brimonidine alone.
Common side effects (may affect up to 1 in 10 people)
• Effects in the eye: allergic conjunctivitis (eye allergy), eye surface inflammation, eye pain, eye discomfort, blurred or abnormal vision, eye redness
• General side effects: drowsiness, dizziness, bad taste in mouth, dry mouth
Uncommon side effects (may affect up to 1 in 100 people)
• Effects in the eye: eye surface damage with loss of cells, inflammation of the eyelid, deposits on
the eye surface, sensitivity to light, swelling of the eye (affecting the cornea or eyelid), dry eye, eye discharge, watery eye, eyelid redness, abnormal or decreased sensation in eye, tired eye,
reduced vision, double vision, product particles in eyes.
• General side effects: decreased blood pressure, chest pain, irregular heartbeat, slow or fast heart rate, palpitations, difficulty sleeping (insomnia), nightmares, depression, generalised weakness, headache, dizziness, nervousness, irritability, general feeling of being unwell, memory loss,
shortness of breath, asthma, nose bleeds, cold symptoms, dry nose or throat, sore throat, throat irritation, cough, runny nose, stuffy nose, sneezing, sinus infection, chest congestion, ringing in
ear, indigestion, intestinal gas or stomach ache, nausea, diarrhoea, vomiting, abnormal sensation in mouth, increased allergic symptoms on skin, rash, abnormal skin sensation, hair loss,
generalised itching, increased blood chlorine levels, or decreased red blood cell count as seen in a blood test, pain, back pain, muscle pain or spasm, kidney pain such as lower back pain, decreased libido, male sexual difficulty.
Very rare (may affect up to 1 in 10,000 people)
• Effects in the eye: decreased pupil size
• General side effects: fainting, increased blood pressure
Not known (frequency cannot be estimated from the available data)
• Effects in the eye: decreased growth of eyelashes
• General side effects: tremor, decreased sensation, loss of taste, abnormal liver function values as seen in a blood test, swelling of the face, joint pain, frequent urination, chest pain, swelling of
the extremities.
Reporting of side effects
If you get any side effects, talk to your doctor, optometrist (optician) or pharmacist. This includes any
possible side effects not listed in this leaflet. You can also report side effects directly (see details
below). By reporting side effects you can help provide more information on the safety of this medicine.
United Kingdom
Yellow Card Scheme
Website : www.mhra.gov.uk / yellowcard or search for MHRA Yellow Card in the Google Play or
Apple App Store
Ingredients
What SIMBRINZA EYE DROPS contains
– The active substances are brinzolamide and brimonidine tartrate. One ml of suspension contains 10 mg of brinzolamide and 2 mg of brimonidine tartrate equivalent to 1.3 mg brimonidine.
– The other ingredients are benzalkonium chloride (see section 2 “Wearing contact lenses –
SIMBRINZA contains benzalkonium chloride”), propylene glycol, carbomer 974P, boric acid, mannitol, sodium chloride, tyloxapol, hydrochloric acid and/or sodium hydroxide and purified water.
Tiny amounts of hydrochloric acid and/or sodium hydroxide are added to keep acidity levels (pH levels) normal
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Rudolph McFarlane (verified owner) –
The item was delivered on time
Bridget Parker (verified owner) –
Just what the doctor ordered !!