• paracetamol which is a pain reliever (analgesic) and helps reduce your temperature when you have a fever
• codeine phosphate which is a pain reliever (analgesic)
• caffeine which helps to increase the pain relief from paracetamol and makes you more alert.

What this medicine is and what it is used for: for the relief of mild to moderate pain

These tablets are for the short term treatment of acute moderate pain which is not relieved by paracetamol, ibuprofen or aspirin alone. This medicine is for the relief of migraine, headache, rheumatic pain, period pain, toothache and nerve pain.

Do not take this medicine if you:

• are allergic to paracetamol, codeine, caffeine or any of the other ingredients of this medicine (listed in section 6)
• have acute asthma
• have severe respiratory disease
• suffer from alcoholism
• have had recent bile duct surgery (e.g. gall stones)
• suffer from paralytic ileus, where your bowel has ceased to function
• have recently had a head injury or raised pressure in the skull
• are breastfeeding
• have been told by your doctor that you are a CYP2D6 ultra metaboliser
• are under 18 years and have had your tonsils or adenoids removed.

Warnings and precautions

Talk to your doctor or pharmacist before taking this medicine, if you

• suffer from kidney or liver problems, including alcoholic liver disease
• have an enlarged prostate gland
• suffer from low blood pressure
• suffer from inflammatory or obstructive bowel disorders such as constipation, diarrhoea or bloating
• suffer from an underactive thyroid gland
• are elderly or debilitated.

Other medicines and Syndol headache relief tablets 

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, like

• medicines to treat high cholesterol levels which reduce the amount of fat in the blood such as colestyramine
• medicines to control feeling sick or being sick such as metoclopramide or domperidone
• medicines called anti-coagulants, which are used to thin the blood such as warfarin, Aspirin or other coumarins – you may take occasional doses of paracetamol but should consult your doctor if you need to take it on a regular basis
• cimetidine, a medicine to treat heartburn or peptic ulcers
• tricyclic antidepressants, which are medicines used to treat depression e.g. amitriptyline and imipramine
• antipsychotic medicines used to treat mental illness e.g. chlorpromazine and risperidone
• quinidine or mexiletine, used to treat heart problems
• antidepressant drugs called monoamine oxidase inhibitors (MAOI’s) – these are medicines such as phenelzine and moclobemide
• the antibiotic chloramphenicol
• other CNS depressant drugs such as sodium oxybate
• barbiturates and benzodiazepines which are medicines to calm you down or to help you sleep (e.g. mephobarbital, pentobarbital, diazepam and alprazolam).
• medicines for diarrhoea and tummy cramps as taking these at the same time as Syndol Headache Relief Tablets may make you constipated.
• medicines such as atropine, procyclidene, or hyoscine which are used to treat problems with gut movement. Taking these at the same time as Syndol Headache Relief Tablets may make you severely constipated and may make it difficult for you to pass urine.
• some antihistamines which may be used in cough/cold remedies and anti-allergy products. Taking these at the same time as paracetamol, caffeine and codeine tablets may make you severely constipated and may make it difficult for you to pass urine.
• naltrexone – used in the treatment of drug dependence.

Do not take anything else containing paracetamol while taking this medicine.

Taking this medicine with food, drink and alcohol

Do not drink alcohol (beer, wine, spirits etc) while taking this product.

Pregnancy and breastfeeding

Do not take this medicine if you are breastfeeding.

If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Driving and using machines

These tablets might cause drowsiness. If you are affected, do not drive or operate machinery.

The medicine can affect your ability to drive as it may make you sleepy or dizzy.

• Do not drive while taking this medicine until you know how it affects you
• It may be an offence to drive when taking this medicine
• However, you would not be committing an offence if:
  • The medicine has been taken to treat a medical or dental problem and
  • You have taken it according to the information provided with the medicine and
  • It was not affecting your ability to drive safely

Talk to your doctor or pharmacist if you are not sure whether it is safe for you to drive while taking this medicine.

Details regarding a new driving offence concerning driving after drugs have been taken in the UK may be found here: https://www.gov.uk/drug-driving-law