Tackle sun-damaged skin effectively with Tolak Cream (Fluorouracil 40mg/g), specially formulated to treat actinic keratosis (AK) on the face, ears, and scalp in adults. Tolak works by destroying pre-cancerous and cancerous cells on the skin, promoting healing while minimizing damage to healthy cells. This targeted treatment helps clear visible and invisible abnormalities caused by sun exposure, offering a powerful solution for skin health.
When you apply Tolak Cream, the affected areas of your skin may turn red as the cream begins to destroy pre-cancerous and cancerous cells. You may experience inflammation, discomfort, and skin erosion before the healing process begins. These reactions are normal and show that the treatment is effective. Complete healing typically takes 2-4 weeks after finishing the treatment course.
While Tolak Cream is effective in treating actinic keratosis, some users may experience side effects, including:
If the skin reaction becomes too severe or painful, consult your healthcare provider for advice. They may prescribe a cream to help soothe any discomfort.
Pregnancy, Breastfeeding, and Fertility
Tolak should not be used during pregnancy. If you become pregnant while using Tolak, stop treatment immediately and contact your doctor for advice regarding the potential risk to your baby.
Women of childbearing potential must use effective contraception during treatment with Tolak and for up to 6 months after the final dose. If you need guidance on contraception options, consult your doctor.
Men using Tolak must also use effective contraception and avoid fathering a child during treatment and for up to 3 months after the last dose.
Tolak Cream offers a targeted, effective solution for treating actinic keratosis caused by sun damage. By addressing both visible and invisible skin damage, it helps prevent the progression of pre-cancerous cells while promoting healthy skin regeneration. Trusted by dermatologists, Tolak is an excellent choice for anyone seeking a reliable, physician-approved treatment for sun-damaged skin.
Take control of sun-damaged skin and prevent actinic keratosis from worsening with Tolak Cream. Order now from Dock Pharmacy for fast, reliable delivery, and begin your journey to healthier skin!
How to use Tolak
Always use this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
How to apply Tolak
Apply Tolak once daily to cover the areas of your skin to be treated, for 4 weeks as follows:
What you need to know before you use Tolak Do not use Tolak: • if you are allergic (hypersensitive) to fluorouracil or any of the other ingredients of this medicine (listed in section 6) • If you are allergic (hypersensitive) to peanut or soya • If you are pregnant • If you are breast-feeding • If you are using any medicines known as antiviral nucleosides (e.g. brivudine and sorivudine). These medicines are usually used to treat chickenpox or shingles. Warnings and precautions Talk to your doctor or pharmacist before using Tolak. • Do not apply Tolak directly into eyes, nose, mouth, or other mucous membranes because irritation, local inflammation and ulceration can occur. • Do not apply Tolak on open wounds or damaged skin. • It is likely that the area of the skin treated will become red, probably followed by inflammation/swelling, possibly some discomfort, skin erosion and eventually, healing. This is the expected normal response to treatment and it shows that Tolak is working. Talk to your doctor if your skin becomes much worse, you experience pain or if you are worried. Your doctor may prescribe you another cream to relieve any discomfort. • Do not apply Tolak under bandages or dressing as this may increase inflammatory reactions of the skin. • To avoid transfer of the drug into the eyes and/or contact lenses and to the area around the eyes during and after application, you should wash hands well after applying Tolak. • If accidental exposure occurs, you should flush eye(s) with large amounts of water. • Allergic reactions (contact eczema) can occur. Tell your doctor if you experience severe itching or if redness develops beyond the treated lesions. • Exposure to UV-radiation (e.g. natural sunlight, tanning salon) should be avoided. • If you know that you have reduced or no activity of the enzyme dihydropyrimidine dehydrogenase (DPD) (partial or complete DPD deficiency) Tolak might cause serious side effects in people who do not have enough of the enzyme dihydropyrimidine dehydrogenase (DPD). Stop using Tolak and call your doctor immediately if you present any of the following symptoms: mouth ulceration (mucositis), stomach-area (abdominal) pain, bloody diarrhea, vomiting, fever and chills. Children and adolescents Tolak is not intended for use in children and adolescents under 18 years of age. Other medicines and Tolak Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines. In particular, tell your doctor if you are using medicines to treat chickenpox or shingles (brivudine and sorivudine) or have used them in the last 4 weeks. These medicines may increase the possibility of unwanted effects with Tolak. Therefore, these medicines must not be used with Tolak. 3 Pregnancy, breast-feeding and fertility Tolak must not be used during pregnancy. If you become pregnant during treatment, Tolak treatment must be interrupted, contact your doctor immediately for advice about the risk for the child. Women of childbearing potential on treatment with Tolak must use an effective contraception during treatment and up to 6 months after the last dose of Tolak. Talk to your doctor if you need advice on contraception. Men under Tolak treatment must use effective contraception and not father a child during treatment and up to 3 months after the last dose of Tolak.
It is not known if Tolak passes into your breast milk. Tolak must not be used during breast-feeding. If use during breastfeeding is absolutely necessary, breastfeeding must be discontinued. The use of Tolak may impair female and male fertility. Tolak is not recommended in women and men attempting to have a child. Driving and using machines It is unlikely that treatment will have any effect on the ability to drive and use machines. Tolak contains : • Butylhydroxytoluene (E321): It may cause local skin reactions (e.g., contact dermatitis), or irritation to the eyes and mucous membranes. • Cetyl alcohol and stearyl alcohol They may cause local skin reactions (e.g., contact dermatitis). • Methyl parahydroxybenzoate (E218) and propyl parahydroxybenzoate They may cause allergic reactions (possibly delayed). • Arachis oil, refined (peanut oil) If you are allergic to peanut or soya, do not use this medicinal product.
Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them. Common side effects (may affect up to 1 in 10 people) – Skin reactions on the site of application (irritation, pain, reaction, redness, itching, inflammation, oedema (swelling)) – Eye irritation Uncommon side effects (may affect up to 1 in 100 people) – Impetigo (bacterial infection of the skin), – Sore throat (pharyngitis), – Insomnia, – Nasal discomfort, – Lip blister, – Nausea, – Swelling around the eyes (oedema), – Increased watery eyes (lacrimation), – Redness, – Skin reactions on the site of application: bleeding, erosion, eczema, discomfort, dryness, burning/tingling, photosensitivity reaction (increase in the reactivity of the skin to sunlight). The frequency of the following side effects is not known (frequency cannot be estimated from the available data) – Allergic reactions (contact eczema) Reporting of side effects If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme Website: https://yellowcard.mhra.gov.uk or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects, you can help provide more information on the safety of this medicine.
What Tolak contains –
The active substance is: fluorouracil –
The other ingredients are: stearoyl macrogolglycerides, butylhydroxytoluene (E321), cetyl alcohol, citric acid (E330), glycerol (E422), isopropyl myristate, methyl gluceth-10, methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate, purified water, Arachis oil, refined (peanut oil), sodium hydroxide (E524), stearic acid, and stearyl alcohol.
How to store Tolak
Keep this medicine out of the sight and reach of children.
Do not store Tolak above 25°C.
Do not use this medicine after the expiry date which is stated on the carton after {EXP}. The expiry date refers to the last day of that month.
Do not use Tolak after 4 weeks following the first opening of the tube (being pierced by the cap). Do not throw away any medicines via wastewater or household waste.
Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
Click here for the Patient Information leaflet
Please read before using the product
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